Activation of the enzyme PLC (phospholipase C) leads to the formation of second messengers Ins(1,4,5)P3 and diacylglycerol. RTKs (receptor tyrosine kinases) activate this reaction through PLCγ isoenzymes. It has been shown that PI3K (phosphoinositide 3-kinase) may regulate PLCγ activity through the interaction of PI3K product PtdIns(3,4,5)P3 and the PLCγ PH domain (pleckstrin homology domain). Here, we analyse the potential functional roles of the PI3K/PLC pathway. ©2007 Biochemical Society.
Phosphoinositide 3-kinase-dependent regulation of phospholipase Cγ / Maffucci, T.; Falasca, M.. - In: BIOCHEMICAL SOCIETY TRANSACTIONS. - ISSN 0300-5127. - 35:2(2007), pp. 229-230. [10.1042/BST0350229]
Phosphoinositide 3-kinase-dependent regulation of phospholipase Cγ
Falasca M.
Writing – Review & Editing
2007-01-01
Abstract
Activation of the enzyme PLC (phospholipase C) leads to the formation of second messengers Ins(1,4,5)P3 and diacylglycerol. RTKs (receptor tyrosine kinases) activate this reaction through PLCγ isoenzymes. It has been shown that PI3K (phosphoinositide 3-kinase) may regulate PLCγ activity through the interaction of PI3K product PtdIns(3,4,5)P3 and the PLCγ PH domain (pleckstrin homology domain). Here, we analyse the potential functional roles of the PI3K/PLC pathway. ©2007 Biochemical Society.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
