Pleckstrin-homology (PH) domains are small protein modules found in more than 100 proteins, most of which require association with the cell membrane to mediate their biological functions. Recent studies have demonstrated that some PH domains bind specifically to phosphoinositides, and that PH-domain-mediated recruitment of certain proteins to the cell membrane is important in regulation of their activities or fuctions. This provides the cell with a simple and efficient mechanism for linking growth-factor-induced changes in the levels of specific membrane phosphoinositides with other signalling pathways that control diverse processes such as protein synthesis, DNA synthesis and cell adhesion.
Regulatory recruitment of signalling molecules to the cell membrane by pleckstrin-homology domains / Lemmon, M. A.; Falasca, M.; Schlessinger, J.. - In: TRENDS IN CELL BIOLOGY. - ISSN 0962-8924. - 7:6(1997), pp. 237-242. [10.1016/S0962-8924(97)01065-9]
Regulatory recruitment of signalling molecules to the cell membrane by pleckstrin-homology domains
Falasca M.Membro del Collaboration Group
;
1997-01-01
Abstract
Pleckstrin-homology (PH) domains are small protein modules found in more than 100 proteins, most of which require association with the cell membrane to mediate their biological functions. Recent studies have demonstrated that some PH domains bind specifically to phosphoinositides, and that PH-domain-mediated recruitment of certain proteins to the cell membrane is important in regulation of their activities or fuctions. This provides the cell with a simple and efficient mechanism for linking growth-factor-induced changes in the levels of specific membrane phosphoinositides with other signalling pathways that control diverse processes such as protein synthesis, DNA synthesis and cell adhesion.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.