: There are similarities in the pathophysiologic mechanisms of atherosclerosis, calcific aortic valve disease (CAVD) and mitral annular calcification (MAC), however, medical treatment to slow or stop the progression of CAVD or MAC has been more elusive as compared to atherosclerosis. Atherosclerosis and CAVD share common demographic, clinical, protein, and genetic factors even more so than with MAC, which supports the possibility of shared medical therapies, though abrogating calcific extracellular vesicle shedding could be a common target for all three conditions. Herein, we summarize the overlapping and distinct pathways for further investigation, as well as key areas where additional research is needed.

Atherosclerosis, calcific aortic valve disease and mitral annular calcification: same or different? / Hafiane, Anouar; Pisaturo, Alessandro; Favari, Elda; Bortnick, Anna E.. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 420:(2025). [10.1016/j.ijcard.2024.132741]

Atherosclerosis, calcific aortic valve disease and mitral annular calcification: same or different?

Favari, Elda
Writing – Original Draft Preparation
;
2025-01-01

Abstract

: There are similarities in the pathophysiologic mechanisms of atherosclerosis, calcific aortic valve disease (CAVD) and mitral annular calcification (MAC), however, medical treatment to slow or stop the progression of CAVD or MAC has been more elusive as compared to atherosclerosis. Atherosclerosis and CAVD share common demographic, clinical, protein, and genetic factors even more so than with MAC, which supports the possibility of shared medical therapies, though abrogating calcific extracellular vesicle shedding could be a common target for all three conditions. Herein, we summarize the overlapping and distinct pathways for further investigation, as well as key areas where additional research is needed.
2025
Atherosclerosis, calcific aortic valve disease and mitral annular calcification: same or different? / Hafiane, Anouar; Pisaturo, Alessandro; Favari, Elda; Bortnick, Anna E.. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 420:(2025). [10.1016/j.ijcard.2024.132741]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/3007673
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