Dysregulated inflammatory signaling is a key feature of myeloproliferative neoplasms (MPNs), most notably of myelofibrosis (MF). Indeed, MF is considered the prototype of onco-inflammatory hematologic cancers. While increased levels of circulatory and bone marrow cytokines are a well-established feature of all MPNs, a very recent body of literature is intriguingly pinpointing the selective overexpression of cytokine receptors by MF hematopoietic stem and progenitor cells (HSPCs), which, by contrast, are nearly absent or scarcely expressed in essential thrombocythemia (ET) or polycythemia vera (PV) cells. This new evidence suggests that MF CD34(+) cells are uniquely capable of sensing inflammation, and that activation of specific cytokine signaling axes may contribute to the peculiar aggressive phenotype and biological behavior of this disorder. In this review, we will cover the main cytokine systems peculiarly activated in MF and how cytokine receptor targeting is shaping a novel therapeutic avenue in this disease.

Functionally Relevant Cytokine/Receptor Axes in Myelofibrosis / Pozzi, G.; Carubbi, C.; Cerreto, G. M.; Scacchi, C.; Cortellazzi, S.; Vitale, M.; Masselli, E.. - In: BIOMEDICINES. - ISSN 2227-9059. - 11:9(2023). [10.3390/biomedicines11092462]

Functionally Relevant Cytokine/Receptor Axes in Myelofibrosis

Pozzi G.;Carubbi C.;Cerreto G. M.;Cortellazzi S.;Vitale M.
;
Masselli E.
2023-01-01

Abstract

Dysregulated inflammatory signaling is a key feature of myeloproliferative neoplasms (MPNs), most notably of myelofibrosis (MF). Indeed, MF is considered the prototype of onco-inflammatory hematologic cancers. While increased levels of circulatory and bone marrow cytokines are a well-established feature of all MPNs, a very recent body of literature is intriguingly pinpointing the selective overexpression of cytokine receptors by MF hematopoietic stem and progenitor cells (HSPCs), which, by contrast, are nearly absent or scarcely expressed in essential thrombocythemia (ET) or polycythemia vera (PV) cells. This new evidence suggests that MF CD34(+) cells are uniquely capable of sensing inflammation, and that activation of specific cytokine signaling axes may contribute to the peculiar aggressive phenotype and biological behavior of this disorder. In this review, we will cover the main cytokine systems peculiarly activated in MF and how cytokine receptor targeting is shaping a novel therapeutic avenue in this disease.
2023
Functionally Relevant Cytokine/Receptor Axes in Myelofibrosis / Pozzi, G.; Carubbi, C.; Cerreto, G. M.; Scacchi, C.; Cortellazzi, S.; Vitale, M.; Masselli, E.. - In: BIOMEDICINES. - ISSN 2227-9059. - 11:9(2023). [10.3390/biomedicines11092462]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2996573
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact