We report an unprecedented iron-catalyzed C−H annulation using readily available 2-vinylbenzofurans as the reaction pattern. The redox-neutral strategy, based on cheap, non-toxic, and earth-abundant iron catalysts, exploits triazole assistance to promote a cascade C−H alkylation, benzofuran ring-opening and insertion into a Fe−N bond, to form highly functionalized isoquinolones. Detailed mechanistic studies supported by DFT calculations fully disclosed the manifold of the iron catalysis.

Iron-Catalyzed C−H Alkylation/Ring Opening with Vinylbenzofurans Enabled by Triazoles / Cattani, S.; Pandit, N. K.; Buccio, M.; Balestri, D.; Ackermann, L.; Cera, G.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 63:32(2024). [10.1002/anie.202404319]

Iron-Catalyzed C−H Alkylation/Ring Opening with Vinylbenzofurans Enabled by Triazoles

Cattani S.;Buccio M.;Balestri D.;Cera G.
2024-01-01

Abstract

We report an unprecedented iron-catalyzed C−H annulation using readily available 2-vinylbenzofurans as the reaction pattern. The redox-neutral strategy, based on cheap, non-toxic, and earth-abundant iron catalysts, exploits triazole assistance to promote a cascade C−H alkylation, benzofuran ring-opening and insertion into a Fe−N bond, to form highly functionalized isoquinolones. Detailed mechanistic studies supported by DFT calculations fully disclosed the manifold of the iron catalysis.
2024
Iron-Catalyzed C−H Alkylation/Ring Opening with Vinylbenzofurans Enabled by Triazoles / Cattani, S.; Pandit, N. K.; Buccio, M.; Balestri, D.; Ackermann, L.; Cera, G.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 63:32(2024). [10.1002/anie.202404319]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2996275
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