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IRIS
ObjectiveTo explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts.MethodsWe performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors and their genetic risk scores (GRS) with MRI-defined BI and a subset of BI, namely, small subcortical BI (SSBI), in 18 population-based cohorts (n = 20,949) from 5 ethnicities (3,726 with BI, 2,021 with SSBI). Top loci were followed up in 7 population-based cohorts (n = 6,862; 1,483 with BI, 630 with SBBI), and we tested associations with related phenotypes including ischemic stroke and pathologically defined BI.ResultsThe mean prevalence was 17.7% for BI and 10.5% for SSBI, steeply rising after age 65. Two loci showed genome-wide significant association with BI: FBN2, p = 1.77 x 10(-8); and LINC00539/ZDHHC20, p = 5.82 x 10(-9). Both have been associated with blood pressure (BP)-related phenotypes, but did not replicate in the smaller follow-up sample or show associations with related phenotypes. Age- and sex-adjusted associations with BI and SSBI were observed for BP traits (p value for BI, p([BI]) = 9.38 x 10(-25); p([SSBI]) = 5.23 x 10(-14) for hypertension), smoking (p([BI]) = 4.4 x 10(-10); p([SSBI]) = 1.2 x 10(-4)), diabetes (p([BI]) = 1.7 x 10(-8); p([SSBI]) = 2.8 x 10(-3)), previous cardiovascular disease (p([BI]) = 1.0 x 10(-18); p([SSBI]) = 2.3 x 10(-7)), stroke (p([BI]) = 3.9 x 10(-69); p([SSBI]) = 3.2 x 10(-24)), and MRI-defined white matter hyperintensity burden (p([BI]) = 1.43 x 10(-157); p([SSBI]) = 3.16 x 10(-106)), but not with body mass index or cholesterol. GRS of BP traits were associated with BI and SSBI (p 0.0022), without indication of directional pleiotropy.ConclusionIn this multiethnic GWAS meta-analysis, including over 20,000 population-based participants, we identified genetic risk loci for BI requiring validation once additional large datasets become available. High BP, including genetically determined, was the most significant modifiable, causal risk factor for BI.
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting / Ganesh, Chauhan; Hieab H. H., Adams; Claudia L., Satizabal; Joshua C., Bis; Alexander, Teumer; Muralidharan, Sargurupremraj; Edith, Hofer; Stella, Trompet; Saima, Hilal; Albert Vernon, Smith; Xueqiu, Jian; Rainer, Malik; Matthew, Traylor; Sara L., Pulit; Philippe, Amouyel; Bernard, Mazoyer; Yi-Cheng, Zhu; Sara, Kaffashian; Sabrina, Schilling; Gary W., Beecham; Thomas J., Montine; Gerard D., Schellenberg; Olafur, Kjartansson; Vilmundur, Guðnason; David S., Knopman; Michael E., Griswold; B. Gwen, Windham; Rebecca F., Gottesman; Thomas H., Mosley; Reinhold, Schmidt; Yasaman, Saba; Helena, Schmidt; Fumihiko, Takeuchi; Shuhei, Yamaguchi; Toru, Nabika; Norihiro, Kato; Kumar B., Rajan; Neelum T., Aggarwal; Philip L., De Jager; Denis A., Evans; Bruce M., Psaty; Jerome I., Rotter; Kenneth, Rice; Oscar L., Lopez; Jiemin, Liao; Christopher, Chen; Ching-Yu, Cheng; Tien Y., Wong; Mohammad K., Ikram; Sven J., van der Lee; Najaf, Amin; Vincent, Chouraki; Anita L., Destefano; Hugo J., Aparicio; Jose R., Romero; Pauline, Maillard; Charles, Decarli; Joanna M., Wardlaw; Maria del C. Valdés, Hernández; Michelle, Luciano; David, Liewald; Ian J., Deary; John M., Starr; Mark E., Bastin; Susana, Muñoz Maniega; P. Eline, Slagboom; Marian, Beekman; Joris, Deelen; Hae-Won, Uh; Robin, Lemmens; Henry, Brodaty; Margaret J., Wright; David, Ames; Giorgio B., Boncoraglio; Jemma C., Hopewell; Ashley H., Beecham; Susan H., Blanton; Clinton B., Wright; Ralph L., Sacco; Wei, Wen; Anbupalam, Thalamuthu; Nicola J., Armstrong; Elizabeth, Chong; Peter R., Schofield; John B., Kwok; Jeroen, van der Grond; David J., Stott; Ian, Ford; J. Wouter, Jukema; Meike W., Vernooij; Albert, Hofman; André G., Uitterlinden; Aad, van der Lugt; Katharina, Wittfeld; Hans J., Grabe; Norbert, Hosten; Bettina, von Sarnowski; Uwe, Völker; Christopher, Levi; Jordi, Jimenez-Conde; Pankaj, Sharma; Cathie L. M., Sudlow; Jonathan, Rosand; Daniel, Woo; John W., Cole; James F., Meschia; Agnieszka, Slowik; Vincent, Thijs; Arne, Lindgren; Olle, Melander; Raji P., Grewal; Tatjana, Rundek; Kathy, Rexrode; Peter M., Rothwell; Donna K., Arnett; Christina, Jern; Julie A., Johnson; Oscar R., Benavente; Sylvia, Wasssertheil-Smoller; Jin-Moo, Lee; Quenna, Wong; Braxton D., Mitchell; Stephen S., Rich; Patrick F., Mcardle; Mirjam I., Geerlings; Yolanda, van der Graaf; Paul I. W., de Bakker; Folkert W., Asselbergs; Velandai, Srikanth; Russell, Thomson; Rebekah, Mcwhirter; Chris, Moran; Michele, Callisaya; Thanh, Phan; Loes C. A., Rutten-Jacobs; Steve, Bevan; Christophe, Tzourio; Karen A., Mather; Perminder S., Sachdev; Cornelia M., van Duijn; Bradford B., Worrall; Martin, Dichgans; Steven J., Kittner; Hugh S., Markus; Mohammad A., Ikram; Myriam, Fornage; Lenore J., Launer; Sudha, Seshadri; W. T., Longstreth; Stéphanie, Debette; Null, Null; Peter, Almgren; Christopher D., Anderson; Donna K., Arnett; John, Attia; Hakan, Ay; Oscar R., Benavente; Steve, Bevan; Robert D., Brown; Mariana, Bustamante; Yu-Ching, Cheng; John W., Cole; Ioana, Cotlarciuc; Carlos, Cruchaga; Paul IW., de Bakker; Hossein, Delavaran; Martin, Dichgans; Gunnar, Engström; Myriam, Fornage; Raji P., Grewal; Laura, Heitsch; Elizabeth, Holliday; Laure, Ibanez; Andreea, Ilinca; Marguerite R., Irvin; Rebecca D., Jackson; Christina, Jern; Jordi, Jimenez-Conde; Julie A., Johnson; Katarina, Jood; Brett M., Kissela; Steven J., Kittner; Dawn O., Kleindorfer; Daniel, Labovitz; Cathy C., Laurie; Jin-Moo, Lee; Robin, Lemmens; Christopher, Levi; Linxin, Li; Arne G., Lindgren; Jane, Maguire; Hugh S., Markus; Patrick F., Mcardle; Olle, Melander; James F., Meschia; Braxton D., Mitchell; Martina, Müller-Nurasyid; Bo, Norrving; Leema Reddy, Peddareddygari; Joanna, Pera; Sara L., Pulit; Kathryn, Rexrode; Marta, Ribasés; Jaume, Roquer; Natalia S., Rost; Peter M., Rothwell; Tatjana, Rundek; Ralph L., Sacco; Reinhold, Schmidt; Pankaj, Sharma; Agnieszka, Slowik; Carolina, Soriano-Tárraga; Tara, Stanne; Konstantin, Stauch; O C., Stine; Cathie LM., Sudlow; Vincent N. S., Thijs; Sylvia, Wasssertheil-Smoller; David, Weir; Stephen R., Williams; Quenna, Wong; Daniel, Woo; Bradford B., Worrall; Huichun, Xu; Sudha, Seshadri; Hyacinth I, Hyacinth; Sandro, Marini; Paul, Nyquist; Cathryn, Lewis; Bjorn, Hansen; Bo, Norrving; Jonathan, Rosand; Alessandro, Biffi; Christina, Kourkoulis; Chris, Anderson; Anne-Katrin, Giese; Ralph, Sacco; Pankaj, Sharma; Jong-Won, Chung; Gyeong-Moon, Kim; Steven, Lubitz; Romain, Bourcier; Joanna, Howson; Alessandra, Granata; Anna, Drazyk; Hugh, Markus; Joanna, Wardlaw; Braxton, Mitchell; John, Cole; Jemma, Hopewell; Robin, Walters; Iain, Turnbull; Bradford, Worrall; Josh, Bis; Alex, Reiner; Raj, Dhar; Laura, Heitsch; Jin-Moo, Lee; Kameshwar, Prasad; Chloé, Sarnowski; Hugo Javier, Aparicio; Qiong, Yang; Daniel, Chasman; Kathryn, Rexrode; Chia-Ling, Phuah; Guiyou, Liu; Mitchell, Elkind; Leslie, Lange; Natalia, Rost; Michael, James; Jill, Stewart; Dina, Vojinovic; Vincent, Thijs; Eugenio, Parati; Giorgio, Boncoraglio; Ramin, Zand; Philippe, Bijlenga; Magdy, Selim; Caspar, Grond-Ginsbach; Daniel, Strbian; Liisa, Tomppo; Hanne, Sallinen; Dorothea, Pfeiffer; Nuria, Torres; Miguel, Barboza; Melanie, Laarman; Roberta, Carriero; Elizabeth, Holliday; Jordi, Jimenez-Conde; Carolina, Soriano; Dipender, Gill; Stephanie, Debette; Aniket, Mishra; Jer-Yuarn, Wu; Tai-Ming, Ko; Silvia, Bione; Katarina, Jood; Turgut, Tatlisumak; Lukas, Holmegaard; Suo, Yue; Anna, Bersano; Joanna, Pera; Agnieszka, Slowik; Christopher, Levi; Kristina, Schlicht; Robin, Lemmens; Toshiharu, Ninomiya; Saskia Lesnik, Oberstein; Tsong-Hai, Lee; Rainer, Malik; Martin, Dichgans; Arne, Lindgren; Johan, Wasselius; Mattias, Drake; Olle, Melander; Martin, Stenman; Andreea, Ilinca; Katherine, Crawford; Umme, Lena; Farrah, Mateen; Hakan, Ay; Ona, Wu; Markus, Schirmer; Steve, Cramer; Polina, Golland; Robert, Brown; James, Meschia; Owen A., Ross; Guillaume, Pare; Mike, Chong; Tatjana, Rundek; Katrina, Gwinn; Christopher, Chen; Jim, Koenig; Eva, Giralt; Danish, Saleheen; Frank-Erik, de Leeuw; Karin, Klijn; Yoichiro, Kamatani; Michiaki, Kubo; Yukinori, Okada; Annie, Pedersen; Maja, Olsson; Juan José, Martín; Huichun, Xu; Eng King, Tan; Petrea, Frid; Chaeyoung, Lee; David, Tregouet; Thomas, Leung; Richard, Choy; Christina, Jern; Keat Wei, Loo; Gabriel, Rinkel; Paulo, Franca; Iscia, Cendes; Caty, Carrera; Israel, Fernandez-Cadenas; Joan, Montaner; Helen, Kim; Mayowa, Owolabi; Reecha, Sofat; Mark, Bakker; Ynte, Ruigrok; Allard, Hauer; Sara L., Pulit; Sander W., van der Laan; Ryan, Irvin; Murali, Sargurupremraj; Alessandro, Pezzini; Foad, Abd-Allah; David, Liebeskind; Matthew, Traylor; Rhea, Tan; John, Danesh; Loes, Rutten-Jacobs; Amanda, Donatti; Wagner, Avelar; Joseph, Broderick; Daniel, Woo; Cathie, Sudlow; Kristiina, Rannikmae; Caitrin Wheeler, Mcdonough; Tom, van Agtmael; Matthew, Walters; Martin, Söderholm; Erik, Lorentzen; Sandra, Olsson; Tara, Stanne; Martina, Olsson; Rufus, Akinyemi; Ioana, Cotlatciuc; Patrick, Mcardle; Tushar, Dave; Steven, Kittner; John, Attia; James E, Faber; Iona, Millwood; Elsa Valdés, Márquez; Michelangelo, Mancuso; Riina, Vibo; Janika, Korv; Jane, Maguire; Myriam, Fornage; Jennifer, Majersik; Adam, Dehavenon; Matthew, Alexander; Michele, Sale; Andrew, Southerland; Debra, Owens; Bruce, Psaty; W. T., Longstreth; Stacey Quintero, Wolfe; Carl, Langefeld; Carlos, Cruchaga; Jan, Konrad; Kevin, Sheth; Guido, Falcone; Kathleen, Donahue; Alexis N, Simpkins; Tan Wei, Liang Byorn; Bernard, Chan; Phil, Clatworthy; Jose, Florez; Eric, Harshfield; Atsushi, Hozawa; Chung, Hsu; Chaur-Jong, Hu; Laure, Ibanez; Masafumi, Ihara; Marcos, Lange; Soo Ji, Lee; I-Hui, Lee; Patricia, Musolino; Hirofumi, Nakatomi; Kwang-Yeol, Park; Stephen S, Rich; Chris, Riley; Joohon, Sung; Hideaki, Suzuki; Katie, Vo; Kazuo, Washida; Laura Garcia, Ibenez; Agnieszka, Slowik; Albert, Hofman; Ale, Algra; Alex P, Reiner; Alexander S F, Doney; Andreas, Gschwendtner; Andreea, Ilinca; Anne-Katrin, Giese; Arne, Lindgren; Astrid M, Vicente; Bo, Norrving; Børge G, Nordestgaard; Braxton D, Mitchell; Bradford B, Worrall; Bruce M, Psaty; Cara L, Carty; Cathie, Sudlow; Christopher D, Anderson; Christopher, Levi; Claudia L, Satizabal; Colin N A, Palmer; Dale M, Gamble; Daniel, Woo; Danish, Saleheen; E Bernd, Ringelstein; Einar, Valdimarsson; Elizabeth, Holliday; Gail, Davies; Ganesh, Chauhan; Gerard, Pasterkamp; Giorgio, Boncoraglio; Gregor, Kuhlenbäumer; Gudmar, Thorleifsson; Guido J, Falcone; Guillame, Pare; Helena, Schmidt; Hossein, Delavaran; Hugh S, Markus; Hugo J, Aparicio; Ian, Deary; Ioana, Cotlarciuc; Israel, Fernandez-Cadenas; James, Meschia; Jemma C, Hopewell; Jingmin, Liu; Joan, Montaner; Joanna, Pera; John, Cole; John R, Attia; Jonathan, Rosand; Jose M, Ferro; Joshua, Bis; Karen, Furie; Kari, Stefansson; Klaus, Berger; Konstantinos, Kostulas; Kristina, Rannikmae; M Arfan, Ikram; Marianne, Benn; Martin, Dichgans; Martin, Farrall; Massimo, Pandolfo; Matthew, Traylor; Matthew, Walters; Michele, Sale; Mike, Nalls; Myriam, Fornage; Natalie R, van Zuydam; Pankaj, Sharma; Patricia, Abrantes; Paul IW, de Bakker; Peter, Higgins; Peter, Lichtner; Peter M, Rothwell; Philippe, Amouyel; Qiong, Yang; Rainer, Malik; Reinhold, Schmidt; Robert, Clarke; Robin, Lemmens; Sander W, van der Laan; Sara L, Pulit; Sherine, Abboud; Sofia A, Oliveira; Solveig, Gretarsdottir; Stephanie, Debette; Stephen R, Williams; Steve, Bevan; Steven J, Kittner; Sudha, Seshadri; Thomas, Mosley; Thomas WK, Battey; Turgut, Tatlisumak; Unnur, Thorsteinsdottir; Vincent NS, Thijs; W T, Longstreth; Wei, Zhao; Wei-Min, Chen; Yu-Ching, Cheng; Marilyn S., Albert; Roger L., Albin; Liana G., Apostolova; Steven E., Arnold; Sanjay, Asthana; Craig S., Atwood; Clinton T., Baldwin; M. Michael, Barmada; Lisa L., Barnes; Sandra, Barral; Thomas G., Beach; James T., Becker; Gary W., Beecham; Duane, Beekly; David A., Bennett; Eileen H., Bigio; Thomas D., Bird; Deborah, Blacker; Bradley F., Boeve; Adam, Boxer; James R., Burke; Jeffrey M., Burns; Joseph D., Buxbaum; Goldie S., Byrd; Guiqing, Cai; Nigel J., Cairns; Laura B., Cantwell; Chuanhai, Cao; Cynthia M., Carlsson; Regina M., Carney; Minerva M., Carrasquillo; Steven L., Carroll; Helena C., Chui; David G., Clark; David H., Cribbs; Elizabeth A., Crocco; Carlos, Cruchaga; Philip L., De Jager; Charles, Decarli; F. Yesim, Demirci; Malcolm, Dick; Dennis W., Dickson; Ranjan, Duara; Nilufer, Ertekin-Taner; Denis A., Evans; Kelley M., Faber; M. Daniele, Fallin; Kenneth B., Fallon; David W., Fardo; Martin R., Farlow; Lindsay A., Farrer; Steven, Ferris; Tatiana M., Foroud; Matthew P., Frosch; Douglas R., Galasko; Marla, Gearing; Daniel H., Geschwind; Bernardino, Ghetti; John R., Gilbert; Rodney C. P., Go; Alison M., Goate; Neill R., Graff-Radford; Robert C., Green; Patrick, Griffith; John H., Growdon; Jonathan L., Haines; Hakon, Hakonarson; Ronald L., Hamilton; Kara L., Hamilton-Nelson; Vahram, Haroutunian; Lindy E., Harrell; Lawrence S., Honig; Ryan M., Huebinger; Christine M., Hulette; Bradley T., Hyman; Gregory A., Jicha; Lee-Way, Jin; Gyungah, Jun; M. Ilyas, Kamboh; Anna, Karydas; John S. K., Kauwe; Jeffrey A., Kaye; Ronald, Kim; Neil W., Kowall; Joel H., Kramer; Walter A., Kukull; Brian W., Kunkle; Frank M., Laferla; James J., Lah; Rosalyn, Lang-Walker; Eric B., Larson; James B., Leverenz; Allan I., Levey; Ge, Li; Andrew P., Lieberman; Mark W., Logue; Oscar L., Lopez; Kathryn L., Lunetta; Constantine G., Lyketsos; Wendy J., Mack; Jennifer J., Manly; Daniel C., Marson; Eden R., Martin; Frank, Martiniuk; Deborah C., Mash; Eliezer, Masliah; Richard, Mayeux; Ann C., Mckee; Marsel, Mesulam; Bruce L., Miller; Carol A., Miller; Joshua W., Miller; Thomas J., Montine; John C., Morris; Jill R., Murrell; Adam C., Naj; Thomas O., Obisesan; John M., Olichney; Vernon S., Pankratz; Joseph E., Parisi; Amanda, Partch; Henry L., Paulson; Margaret A., Pericak-Vance; William, Perry; Elaine, Peskind; Ronald C., Petersen; Aimee, Pierce; Wayne W., Poon; Huntington, Potter; Joseph F., Quinn; Ashok, Raj; Towfique, Raj; Murray, Raskind; Eric M., Reiman; Barry, Reisberg; Christiane, Reitz; John M., Ringman; Erik D., Roberson; Howard J., Rosen; Roger N., Rosenberg; Mark A., Sager; Mary, Sano; Andrew J., Saykin; Gerard D., Schellenberg; Julie A., Schneider; Lon S., Schneider; William W., Seeley; Amanda G., Smith; Joshua A., Sonnen; Salvatore, Spina; Robert A., Stern; Russell H., Swerdlow; Rudolph E., Tanzi; Tricia A., Thornton-Wells; John Q., Trojanowski; Juan C., Troncoso; Debby W., Tsuang; Otto, Valladares; Vivianna M., Van Deerlin; Linda J., Van Eldik; Badri N., Vardarajan; Harry V., Vinters; Jean Paul, Vonsattel; Li-San, Wang; Sandra, Weintraub; Kathleen A., Welsh-Bohmer; Jennifer, Williamson; Thomas S., Wingo; Sarah, Wishnek; Randall L., Woltjer; Clinton B., Wright; Steven G., Younkin; Chang-En, Yu; Lei, Yu; Ganesh, Chauhan; Audrey Y., Chu; Myriam, Fornage; Joshua C., Bis; Aki S., Havulinna; Muralidharan, Sargurupremraj; Albert Vernon, Smith; Hieab H. H., Adams; Seung Hoan, Choi; Stella, Trompet; Melissa E., Garcia; Ani, Manichaikul; Alexander, Teumer; Stefan, Gustafsson; Traci M., Bartz; Céline, Bellenguez; Jean Sebastien, Vidal; Xueqiu, Jian; Olafur, Kjartansson; Kerri L., Wiggins; Claudia L., Satizabal; Flora, Xue; Samuli, Ripatti; Yongmei, Liu; Joris, Deelen; Marcel den, Hoed; Susan R., Heckbert; Kenneth, Rice; Nicholas L., Smith; Quenna, Wong; Hugo J., Aparicio; Julie E., Buring; Paul M, Ridker; Claudine, Berr; Jean-François, Dartigues; Anders, Hamsten; Patrik K., Magnusson; Nancy L., Pedersen; Lars, Lannfelt; Lars, Lind; Cecilia M., Lindgren; Andrew P., Morris; Albert, Hofman; Peter J., Koudstaal; Marileen LP., Portegies; André G., Uitterlinden; Anton JM, de Craen; Ian, Ford; J. Wouter, Jukema; David J, Stott; Norrina B., Allen; Michele M., Sale; Andrew D, Johnson; David A., Bennett; Philip L., De Jager; Charles C., White; Hans Jörgen, Grabe; Marcello Ricardo, Paulista Markus; Oscar L, Lopez; Jerome I., Rotter; Michael A., Nalls; Rebecca F., Gottesman; Michael E., Griswold; David S., Knopman; B. Gwen, Windham; Alexa, Beiser; Erkki, Vartiainen; Curtis R., French; Tobias, Kurth; Bruce M., Psaty; Tamara B., Harris; Stephen S, Rich; Anita L., Destefano; Carsten Oliver, Schmidt; Veikko, Salomaa; Thomas H., Mosley; Erik, Ingelsson; Cornelia M., van Duijn; Christophe, Tzourio; Lenore J, Launer; M. Arfan, Ikram; Daniel I., Chasman; W. T., Longstreth; Sudha, Seshadri; Stéphanie, Debette; Benjamin F. J., Verhaaren; Stéphanie, Debette; Joshua C., Bis; Jennifer A., Smith; M. Kamran, Ikram; Hieab H., Adams; Ashley H., Beecham; Kumar B., Rajan; Lorna M., Lopez; Sandra, Barral; Mark A., van Buchem; Jeroen, van der Grond; Albert V., Smith; Katrin, Hegenscheid; Neelum T., Aggarwal; Mariza, de Andrade; Elizabeth J., Atkinson; Marian, Beekman; Alexa S., Beiser; Susan H., Blanton; Eric, Boerwinkle; Adam M., Brickman; R. Nick, Bryan; Ganesh, Chauhan; Christopher P. L. H., Chen; Vincent, Chouraki; Anton J. M., de Craen; Fabrice, Crivello; Ian J., Deary; Joris, Deelen; Philip L., De Jager; Carole, Dufouil; Mitchell S. V., Elkind; Denis A., Evans; Paul, Freudenberger; Rebecca F., Gottesman; Vilmundur, Guðnason; Mohamad, Habes; Susan R., Heckbert; Gerardo, Heiss; Saima, Hilal; Edith, Hofer; Albert, Hofman; Carla A., Ibrahim-Verbaas; David S., Knopman; Cora E., Lewis; Jiemin, Liao; David C. M., Liewald; Michelle, Luciano; Aad, van der Lugt; Oliver O., Martinez; Richard, Mayeux; Bernard, Mazoyer; Mike, Nalls; Matthias, Nauck; Wiro J., Niessen; Ben A., Oostra; Bruce M., Psaty; Kenneth M., Rice; Jerome I., Rotter; Bettina, von Sarnowski; Helena, Schmidt; Pamela J., Schreiner; Maaike, Schuur; Stephen S., Sidney; Sigurdur, Sigurdsson; P. Eline, Slagboom; David J. M., Stott; John C., van Swieten; Alexander, Teumer; Anna Maria, Töglhofer; Matthew, Traylor; Stella, Trompet; Stephen T., Turner; Christophe, Tzourio; Hae-Won, Uh; André G., Uitterlinden; Meike W., Vernooij; Jing J., Wang; Tien Y., Wong; Joanna M., Wardlaw; B. Gwen, Windham; Katharina, Wittfeld; Christiane, Wolf; Clinton B., Wright; Qiong, Yang; Wei, Zhao; Alex, Zijdenbos; J. Wouter, Jukema; Ralph L., Sacco; Sharon L. R., Kardia; Philippe, Amouyel; Thomas H., Mosley; W. T., Longstreth; Charles C., Decarli; Cornelia M., van Duijn; Reinhold, Schmidt; Lenore J., Launer; Hans J., Grabe; Sudha S., Seshadri; M. Arfan, Ikram; Myriam, Fornage; Joshua C., Bis; Maryam, Kavousi; Nora, Franceschini; Aaron, Isaacs; Gonçalo R, Abecasis; Ulf, Schminke; Wendy, Post; Albert V., Smith; L. Adrienne, Cupples; Hugh S, Markus; Reinhold, Schmidt; Jennifer E., Huffman; Terho, Lehtimäki; Jens, Baumert; Thomas, Münzel; Susan R., Heckbert; Abbas, Dehghan; Kari, North; Ben, Oostra; Steve, Bevan; Eva-Maria, Stoegerer; Caroline, Hayward; Olli, Raitakari; Christa, Meisinger; Arne, Schillert; Serena, Sanna; Henry, Völzke; Yu-Ching, Cheng; Bolli, Thorsson; Caroline S., Fox; Kenneth, Rice; Fernando, Rivadeneira; Vijay, Nambi; Eran, Halperin; Katja E., Petrovic; Leena, Peltonen; H. Erich, Wichmann; Renate B., Schnabel; Marcus, Dörr; Afshin, Parsa; Thor, Aspelund; Serkalem, Demissie; Sekar, Kathiresan; Muredach P., Reilly; Kent, Taylor; Andre, Uitterlinden; David J., Couper; Matthias, Sitzer; Mika, Kähönen; Thomas, Illig; Philipp S., Wild; Marco, Orru; Jan, Lüdemann; Alan R., Shuldiner; Gudny, Eiriksdottir; Charles C., White; Jerome I., Rotter; Albert, Hofman; Jochen, Seissler; Tanja, Zeller; Gianluca, Usala; Florian, Ernst; Lenore J., Launer; Ralph B., D'Agostino; Daniel H., O'Leary; Christie, Ballantyne; Joachim, Thiery; Andreas, Ziegler; Edward G., Lakatta; Ravi Kumar, Chilukoti; Tamara B., Harris; Philip A., Wolf; Bruce M., Psaty; Joseph F, Polak; Xia, Li; Wolfgang, Rathmann; Manuela, Uda; Eric, Boerwinkle; Norman, Klopp; Helena, Schmidt; James F, Wilson; Jorma, Viikari; Wolfgang, Koenig; Stefan, Blankenberg; Anne B., Newman; Jacqueline, Witteman; Gerardo, Heiss; Cornelia, van Duijn; Angelo, Scuteri; Georg, Homuth; Braxton D., Mitchell; Vilmundur, Gudnason; Christopher J, O'Donnell; Almgren, Peter; D Anderson, Christopher; K Arnett, Donna; Attia, John; Ay, Hakan; R Benavente, Oscar; Bevan, Steve; D Brown, Robert; Bustamante, Mariana; Cheng, Yu-Ching; W Cole, John; Cotlarciuc, Ioana; Cruchaga, Carlos; Iw de Bakker, Paul; Delavaran, Hossein; Dichgans, Martin; Engström, Gunnar; Fornage, Myriam; P Grewal, Raji; Heitsch, Laura; Holliday, Elizabeth; Ibanez, Laure; Ilinca, Andreea; R Irvin, Marguerite; D Jackson, Rebecca; Jern, Christina; Jimenez-Conde, Jordi; A Johnson, Julie; Jood, Katarina; M Kissela, Brett; J Kittner, Steven; O Kleindorfer, Dawn; Labovitz, Daniel; C Laurie, Cathy; Lee, Jin-Moo; Lemmens, Robin; Levi, Christopher; Li, Linxin; G Lindgren, Arne; Maguire, Jane; S Markus, Hugh; F McArdle, Patrick; Melander, Olle; F Meschia, James; D Mitchell, Braxton; Müller-Nurasyid, Martina; Norrving, Bo; Reddy Peddareddygari, Leema; Pera, Joanna; L Pulit, Sara; Rexrode, Kathryn; Ribasés, Marta; Roquer, Jaume; S Rost, Natalia; M Rothwell, Peter; Rundek, Tatjana; L Sacco, Ralph; Schmidt, Reinhold; Sharma, Pankaj; Slowik, Agnieszka; Soriano-Tárraga, Carolina; Stanne, Tara; Stauch, Konstantin; C Stine, O; Lm Sudlow, Cathie; S Thijs, Vincent N; Wasssertheil-Smoller, Sylvia; Weir, David; R Williams, Stephen; Wong, Quenna; Woo, Daniel; B Worrall, Bradford; Xu, Huichun; Seshadri, Sudha; Hyacinth, I Hyacinth; Marini, Sandro; Nyquist, Paul; Lewis, Cathryn; Hansen, Bjorn; Norrving, Bo; Rosand, Jonathan; Biffi, Alessandro; Kourkoulis, Christina; Anderson, Chris; Giese, Anne-Katrin; Sacco, Ralph; Sharma, Pankaj; Chung, Jong-Won; Kim, Gyeong-Moon; Lubitz, Steven; Bourcier, Romain; Howson, Joanna; Granata, Alessandra; Drazyk, Anna; Markus, Hugh; Wardlaw, Joanna; Mitchell, Braxton; Cole, John; Hopewell, Jemma; Walters, Robin; Turnbull, Iain; Worrall, Bradford; Bis, Josh; Reiner, Alex; Dhar, Raj; Heitsch, Laura; Lee, Jin-Moo; Prasad, Kameshwar; Sarnowski, Chloé; Javier Aparicio, Hugo; Yang, Qiong; Chasman, Daniel; Rexrode, Kathryn; Phuah, Chia-Ling; Liu, Guiyou; Elkind, Mitchell; Lange, Leslie; Rost, Natalia; James, Michael; Stewart, Jill; Vojinovic, Dina; Thijs, Vincent; Parati, Eugenio; Boncoraglio, Giorgio; Zand, Ramin; Bijlenga, Philippe; Selim, Magdy; Grond-Ginsbach, Caspar; Strbian, Daniel; Tomppo, Liisa; Sallinen, Hanne; Pfeiffer, Dorothea; Torres, Nuria; Barboza, Miguel; Laarman, Melanie; Carriero, Roberta; Holliday, Elizabeth; Jimenez-Conde, Jordi; Soriano, Carolina; Gill, Dipender; Debette, Stephanie; Mishra, Aniket; Wu, Jer-Yuarn; Ko, Tai-Ming; Bione, Silvia; Jood, Katarina; Tatlisumak, Turgut; Holmegaard, Lukas; Yue, Suo; Bersano, Anna; Pera, Joanna; Slowik, Agnieszka; Levi, Christopher; Schlicht, Kristina; Lemmens, Robin; Ninomiya, Toshiharu; Lesnik Oberstein, Saskia; Lee, Tsong-Hai; Malik, Rainer; Dichgans, Martin; Lindgren, Arne; Wasselius, Johan; Drake, Mattias; Melander, Olle; Stenman, Martin; Ilinca, Andreea; Crawford, Katherine; Lena, Umme; Mateen, Farrah; Ay, Hakan; Wu, Ona; Schirmer, Markus; Cramer, Steve; Golland, Polina; Brown, Robert; Meschia, James; A Ross, Owen; Pare, Guillaume; Chong, Mike; Rundek, Tatjana; Gwinn, Katrina; Chen, Christopher; Koenig, Jim; Giralt, Eva; Saleheen, Danish; de Leeuw, Frank-Erik; Klijn, Karin; Kamatani, Yoichiro; Kubo, Michiaki; Okada, Yukinori; Pedersen, Annie; Olsson, Maja; José Martín, Juan; Xu, Huichun; King Tan, Eng; Frid, Petrea; Lee, Chaeyoung; Tregouet, David; Leung, Thomas; Choy, Richard; Jern, Christina; Wei Loo, Keat; Rinkel, Gabriel; Franca, Paulo; Cendes, Iscia; Carrera, Caty; Fernandez-Cadenas, Israel; Montaner, Joan; Kim, Helen; Owolabi, Mayowa; Sofat, Reecha; Bakker, Mark; Ruigrok, Ynte; Hauer, Allard; L Pulit, Sara; W van der Laan, Sander; Irvin, Ryan; Sargurupremraj, Murali; Pezzini, Alessandro; Abd-Allah, Foad; Liebeskind, David; Traylor, Matthew; Tan, Rhea; Danesh, John; Rutten-Jacobs, Loes; Donatti, Amanda; Avelar, Wagner; Broderick, Joseph; Woo, Daniel; Sudlow, Cathie; Rannikmae, Kristiina; Wheeler McDonough, Caitrin; van Agtmael, Tom; Walters, Matthew; Söderholm, Martin; Lorentzen, Erik; Olsson, Sandra; Stanne, Tara; Olsson, Martina; Akinyemi, Rufus; Cotlatciuc, Ioana; Mcardle, Patrick; Dave, Tushar; Kittner, Steven; Attia, John; E Faber, James; Millwood, Iona; Valdés Márquez, Elsa; Mancuso, Michelangelo; Vibo, Riina; Korv, Janika; Maguire, Jane; Fornage, Myriam; Majersik, Jennifer; Dehavenon, Adam; Alexander, Matthew; Sale, Michele; Southerland, Andrew; Owens, Debra; Psaty, Bruce; T Longstreth Jr, W; Quintero Wolfe, Stacey; Langefeld, Carl; Cruchaga, Carlos; Konrad, Jan; Sheth, Kevin; Falcone, Guido; Donahue, Kathleen; N Simpkins, Alexis; Wei Liang Byorn, Tan; Chan, Bernard; Clatworthy, Phil; Florez, Jose; Harshfield, Eric; Hozawa, Atsushi; Hsu, Chung; Hu, Chaur-Jong; Ibanez, Laure; Ihara, Masafumi; Lange, Marcos; Ji Lee, Soo; Lee, I-Hui; Musolino, Patricia; Nakatomi, Hirofumi; Park, Kwang-Yeol; S Rich, Stephen; Riley, Chris; Sung, Joohon; Suzuki, Hideaki; Vo, Katie; Washida, Kazuo; Garcia Ibenez, Laura; Slowik, Agnieszka; Hofman, Albert; Algra, Ale; P Reiner, Alex; F Doney, Alexander S; Gschwendtner, Andreas; Ilinca, Andreea; Giese, Anne-Katrin; Lindgren, Arne; M Vicente, Astrid; Norrving, Bo; G Nordestgaard, Børge; D Mitchell, Braxton; B Worrall, Bradford; M Psaty, Bruce; L Carty, Cara; Sudlow, Cathie; D Anderson, Christopher; Levi, Christopher; L Satizabal, Claudia; A Palmer, Colin N; M Gamble, Dale; Woo, Daniel; Saleheen, Danish; Bernd Ringelstein, E; Valdimarsson, Einar; Holliday, Elizabeth; Davies, Gail; Chauhan, Ganesh; Pasterkamp, Gerard; Boncoraglio, Giorgio; Kuhlenbäumer, Gregor; Thorleifsson, Gudmar; J Falcone, Guido; Pare, Guillame; Schmidt, Helena; Delavaran, Hossein; S Markus, Hugh; J Aparicio, Hugo; Deary, Ian; Cotlarciuc, Ioana; Fernandez-Cadenas, Israel; Meschia, James; C Hopewell, Jemma; Liu, Jingmin; Montaner, Joan; Pera, Joanna; Cole, John; R Attia, John; Rosand, Jonathan; M Ferro, Jose; Bis, Joshua; Furie, Karen; Stefansson, Kari; Berger, Klaus; Kostulas, Konstantinos; Rannikmae, Kristina; Arfan Ikram, M; Benn, Marianne; Dichgans, Martin; Farrall, Martin; Pandolfo, Massimo; Traylor, Matthew; Walters, Matthew; Sale, Michele; Nalls, Mike; Fornage, Myriam; R van Zuydam, Natalie; Sharma, Pankaj; Abrantes, Patricia; Iw de Bakker, Paul; Higgins, Peter; Lichtner, Peter; M Rothwell, Peter; Amouyel, Philippe; Yang, Qiong; Malik, Rainer; Schmidt, Reinhold; Clarke, Robert; Lemmens, Robin; W van der Laan, Sander; L Pulit, Sara; Abboud, Sherine; A Oliveira, Sofia; Gretarsdottir, Solveig; Debette, Stephanie; R Williams, Stephen; Bevan, Steve; J Kittner, Steven; Seshadri, Sudha; Mosley, Thomas; Wk Battey, Thomas; Tatlisumak, Turgut; Thorsteinsdottir, Unnur; Ns Thijs, Vincent; T Longstreth, W; Zhao, Wei; Chen, Wei-Min; Cheng, Yu-Ching; S Albert, Marilyn; L Albin, Roger; G Apostolova, Liana; E Arnold, Steven; Asthana, Sanjay; S Atwood, Craig; T Baldwin, Clinton; Michael Barmada, M; L Barnes, Lisa; Barral, Sandra; G Beach, Thomas; T Becker, James; W Beecham, Gary; Beekly, Duane; A Bennett, David; H Bigio, Eileen; D Bird, Thomas; Blacker, Deborah; F Boeve, Bradley; Boxer, Adam; R Burke, James; M Burns, Jeffrey; D Buxbaum, Joseph; S Byrd, Goldie; Cai, Guiqing; J Cairns, Nigel; B Cantwell, Laura; Cao, Chuanhai; M Carlsson, Cynthia; M Carney, Regina; M Carrasquillo, Minerva; L Carroll, Steven; C Chui, Helena; G Clark, David; H Cribbs, David; A Crocco, Elizabeth; Cruchaga, Carlos; L De Jager, Philip; Decarli, Charles; Yesim Demirci, F; Dick, Malcolm; W Dickson, Dennis; Duara, Ranjan; Ertekin-Taner, Nilufer; A Evans, Denis; M Faber, Kelley; Daniele Fallin, M; B Fallon, Kenneth; W Fardo, David; R Farlow, Martin; A Farrer, Lindsay; Ferris, Steven; M Foroud, Tatiana; P Frosch, Matthew; R Galasko, Douglas; Gearing, Marla; H Geschwind, Daniel; Ghetti, Bernardino; R Gilbert, John; P Go, Rodney C; M Goate, Alison; R Graff-Radford, Neill; C Green, Robert; Griffith, Patrick; H Growdon, John; L Haines, Jonathan; Hakonarson, Hakon; L Hamilton, Ronald; L Hamilton-Nelson, Kara; Haroutunian, Vahram; E Harrell, Lindy; S Honig, Lawrence; M Huebinger, Ryan; M Hulette, Christine; T Hyman, Bradley; A Jicha, Gregory; Jin, Lee-Way; Jun, Gyungah; Ilyas Kamboh, M; Karydas, Anna; K Kauwe, John S; A Kaye, Jeffrey; Kim, Ronald; W Kowall, Neil; H Kramer, Joel; A Kukull, Walter; W Kunkle, Brian; M LaFerla, Frank; J Lah, James; Lang-Walker, Rosalyn; B Larson, Eric; B Leverenz, James; I Levey, Allan; Li, Ge; P Lieberman, Andrew; W Logue, Mark; L Lopez, Oscar; L Lunetta, Kathryn; G Lyketsos, Constantine; J Mack, Wendy; J Manly, Jennifer; C Marson, Daniel; R Martin, Eden; Martiniuk, Frank; C Mash, Deborah; Masliah, Eliezer; Mayeux, Richard; C McKee, Ann; Mesulam, Marsel; L Miller, Bruce; A Miller, Carol; W Miller, Joshua; J Montine, Thomas; C Morris, John; R Murrell, Jill; C Naj, Adam; O Obisesan, Thomas; M Olichney, John; S Pankratz, Vernon; E Parisi, Joseph; Partch, Amanda; L Paulson, Henry; A Pericak-Vance, Margaret; Perry, William; Peskind, Elaine; C Petersen, Ronald; Pierce, Aimee; W Poon, Wayne; Potter, Huntington; F Quinn, Joseph; Raj, Ashok; Raj, Towfique; Raskind, Murray; M Reiman, Eric; Reisberg, Barry; Reitz, Christiane; M Ringman, John; D Roberson, Erik; J Rosen, Howard; N Rosenberg, Roger; A Sager, Mark; Sano, Mary; J Saykin, Andrew; D Schellenberg, Gerard; A Schneider, Julie; S Schneider, Lon; W Seeley, William; G Smith, Amanda; A Sonnen, Joshua; Spina, Salvatore; A Stern, Robert; H Swerdlow, Russell; E Tanzi, Rudolph; A Thornton-Wells, Tricia; Q Trojanowski, John; C Troncoso, Juan; W Tsuang, Debby; Valladares, Otto; M Van Deerlin, Vivianna; J Van Eldik, Linda; N Vardarajan, Badri; V Vinters, Harry; Paul Vonsattel, Jean; Wang, Li-San; Weintraub, Sandra; A Welsh-Bohmer, Kathleen; Williamson, Jennifer; S Wingo, Thomas; Wishnek, Sarah; L Woltjer, Randall; B Wright, Clinton; G Younkin, Steven; Yu, Chang-En; Yu, Lei; Chauhan, Ganesh; Y Chu, Audrey; Fornage, Myriam; C Bis, Joshua; S Havulinna, Aki; Sargurupremraj, Muralidharan; Vernon Smith, Albert; H Adams, Hieab H; Hoan Choi, Seung; Trompet, Stella; E Garcia, Melissa; Manichaikul, Ani; Teumer, Alexander; Gustafsson, Stefan; M Bartz, Traci; Bellenguez, Céline; Sebastien Vidal, Jean; Jian, Xueqiu; Kjartansson, Olafur; L Wiggins, Kerri; L Satizabal, Claudia; Xue, Flora; Ripatti, Samuli; Liu, Yongmei; Deelen, Joris; den Hoed, Marcel; R Heckbert, Susan; Rice, Kenneth; L Smith, Nicholas; Wong, Quenna; J Aparicio, Hugo; E Buring, Julie; M Ridker, Paul; Berr, Claudine; Dartigues, Jean-François; Hamsten, Anders; K Magnusson, Patrik; L Pedersen, Nancy; Lannfelt, Lars; Lind, Lars; M Lindgren, Cecilia; P Morris, Andrew; Hofman, Albert; J Koudstaal, Peter; Lp Portegies, Marileen; G Uitterlinden, André; Jm de Craen, Anton; Ford, Ian; Wouter Jukema, J; J Stott, David; B Allen, Norrina; M Sale, Michele; D Johnson, Andrew; A Bennett, David; L De Jager, Philip; C White, Charles; Jörgen Grabe, Hans; Ricardo Paulista Markus, Marcello; L Lopez, Oscar; I Rotter, Jerome; A Nalls, Michael; F Gottesman, Rebecca; E Griswold, Michael; S Knopman, David; Gwen Windham, B; Beiser, Alexa; Vartiainen, Erkki; R French, Curtis; Kurth, Tobias; M Psaty, Bruce; B Harris, Tamara; S Rich, Stephen; L deStefano, Anita; Oliver Schmidt, Carsten; Salomaa, Veikko; H Mosley, Thomas; Ingelsson, Erik; M van Duijn, Cornelia; Tzourio, Christophe; J Launer, Lenore; Arfan Ikram, M; I Chasman, Daniel; T Longstreth Jr, W; Seshadri, Sudha; Debette, Stéphanie; J Verhaaren, Benjamin F; Debette, Stéphanie; C Bis, Joshua; A Smith, Jennifer; Kamran Ikram, M; H Adams, Hieab; H Beecham, Ashley; B Rajan, Kumar; M Lopez, Lorna; Barral, Sandra; A van Buchem, Mark; van der Grond, Jeroen; V Smith, Albert; Hegenscheid, Katrin; T Aggarwal, Neelum; de Andrade, Mariza; J Atkinson, Elizabeth; Beekman, Marian; S Beiser, Alexa; H Blanton, Susan; Boerwinkle, Eric; M Brickman, Adam; Nick Bryan, R; Chauhan, Ganesh; H Chen, Christopher P L; Chouraki, Vincent; M de Craen, Anton J; Crivello, Fabrice; J Deary, Ian; Deelen, Joris; L De Jager, Philip; Dufouil, Carole; V Elkind, Mitchell S; A Evans, Denis; Freudenberger, Paul; F Gottesman, Rebecca; Guðnason, Vilmundur; Habes, Mohamad; R Heckbert, Susan; Heiss, Gerardo; Hilal, Saima; Hofer, Edith; Hofman, Albert; A Ibrahim-Verbaas, Carla; S Knopman, David; E Lewis, Cora; Liao, Jiemin; M Liewald, David C; Luciano, Michelle; van der Lugt, Aad; O Martinez, Oliver; Mayeux, Richard; Mazoyer, Bernard; Nalls, Mike; Nauck, Matthias; J Niessen, Wiro; A Oostra, Ben; M Psaty, Bruce; M Rice, Kenneth; I Rotter, Jerome; von Sarnowski, Bettina; Schmidt, Helena; J Schreiner, Pamela; Schuur, Maaike; S Sidney, Stephen; Sigurdsson, Sigurdur; Eline Slagboom, P; M Stott, David J; C van Swieten, John; Teumer, Alexander; Maria Töglhofer, Anna; Traylor, Matthew; Trompet, Stella; T Turner, Stephen; Tzourio, Christophe; Uh, Hae-Won; G Uitterlinden, André; W Vernooij, Meike; J Wang, Jing; Y Wong, Tien; M Wardlaw, Joanna; Gwen Windham, B; Wittfeld, Katharina; Wolf, Christiane; B Wright, Clinton; Yang, Qiong; Zhao, Wei; Zijdenbos, Alex; Wouter Jukema, J; L Sacco, Ralph; R Kardia, Sharon L; Amouyel, Philippe; H Mosley, Thomas; T Longstreth Jr, W; C DeCarli, Charles; M van Duijn, Cornelia; Schmidt, Reinhold; J Launer, Lenore; J Grabe, Hans; S Seshadri, Sudha; Arfan Ikram, M; Fornage, Myriam; C Bis, Joshua; Kavousi, Maryam; Franceschini, Nora; Isaacs, Aaron; R Abecasis, Gonçalo; Schminke, Ulf; Post, Wendy; V Smith, Albert; Adrienne Cupples, L; S Markus, Hugh; Schmidt, Reinhold; E Huffman, Jennifer; Lehtimäki, Terho; Baumert, Jens; Münzel, Thomas; R Heckbert, Susan; Dehghan, Abbas; North, Kari; Oostra, Ben; Bevan, Steve; Stoegerer, Eva-Maria; Hayward, Caroline; Raitakari, Olli; Meisinger, Christa; Schillert, Arne; Sanna, Serena; Völzke, Henry; Cheng, Yu-Ching; Thorsson, Bolli; S Fox, Caroline; Rice, Kenneth; Rivadeneira, Fernando; Nambi, Vijay; Halperin, Eran; E Petrovic, Katja; Peltonen, Leena; Erich Wichmann, H; B Schnabel, Renate; Dörr, Marcus; Parsa, Afshin; Aspelund, Thor; Demissie, Serkalem; Kathiresan, Sekar; P Reilly, Muredach; Taylor, Kent; Uitterlinden, Andre; J Couper, David; Sitzer, Matthias; Kähönen, Mika; Illig, Thomas; S Wild, Philipp; Orru, Marco; Lüdemann, Jan; R Shuldiner, Alan; Eiriksdottir, Gudny; C White, Charles; I Rotter, Jerome; Hofman, Albert; Seissler, Jochen; Zeller, Tanja; Usala, Gianluca; Ernst, Florian; J Launer, Lenore; B D'Agostino Sr, Ralph; H O'Leary, Daniel; Ballantyne, Christie; Thiery, Joachim; Ziegler, Andreas; G Lakatta, Edward; Kumar Chilukoti, Ravi; B Harris, Tamara; A Wolf, Philip; M Psaty, Bruce; F Polak, Joseph; Li, Xia; Rathmann, Wolfgang; Uda, Manuela; Boerwinkle, Eric; Klopp, Norman; Schmidt, Helena; F Wilson, James; Viikari, Jorma; Koenig, Wolfgang; Blankenberg, Stefan; B Newman, Anne; Witteman, Jacqueline; Heiss, Gerardo; van Duijn, Cornelia; Scuteri, Angelo; Homuth, Georg; D Mitchell, Braxton; Gudnason, Vilmundur; J O'Donnell, Christopher. - In: NEUROLOGY. - ISSN 0028-3878. - 92:5(2019). [10.1212/wnl.0000000000006851]
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
Chauhan, Ganesh;Adams, Hieab H. H.;Satizabal, Claudia L.;Bis, Joshua C.;Teumer, Alexander;Sargurupremraj, Muralidharan;Hofer, Edith;Trompet, Stella;Hilal, Saima;Smith, Albert Vernon;Jian, Xueqiu;Malik, Rainer;Traylor, Matthew;Pulit, Sara L.;Amouyel, Philippe;Mazoyer, Bernard;Zhu, Yi-Cheng;Kaffashian, Sara;Schilling, Sabrina;Beecham, Gary W.;Montine, Thomas J.;Schellenberg, Gerard D.;Kjartansson, Olafur;Guðnason, Vilmundur;Knopman, David S.;Griswold, Michael E.;Windham, B. Gwen;Gottesman, Rebecca F.;Mosley, Thomas H.;Schmidt, Reinhold;Saba, Yasaman;Schmidt, Helena;Takeuchi, Fumihiko;Yamaguchi, Shuhei;Nabika, Toru;Kato, Norihiro;Rajan, Kumar B.;Aggarwal, Neelum T.;De Jager, Philip L.;Evans, Denis A.;Psaty, Bruce M.;Rotter, Jerome I.;Rice, Kenneth;Lopez, Oscar L.;Liao, Jiemin;Chen, Christopher;Cheng, Ching-Yu;Wong, Tien Y.;Ikram, Mohammad K.;van der Lee, Sven J.;Amin, Najaf;Chouraki, Vincent;DeStefano, Anita L.;Aparicio, Hugo J.;Romero, Jose R.;Maillard, Pauline;DeCarli, Charles;Wardlaw, Joanna M.;Hernández, Maria del C. Valdés;Luciano, Michelle;Liewald, David;Deary, Ian J.;Starr, John M.;Bastin, Mark E.;Muñoz Maniega, Susana;Slagboom, P. Eline;Beekman, Marian;Deelen, Joris;Uh, Hae-Won;Lemmens, Robin;Brodaty, Henry;Wright, Margaret J.;Ames, David;Boncoraglio, Giorgio B.;Hopewell, Jemma C.;Beecham, Ashley H.;Blanton, Susan H.;Wright, Clinton B.;Sacco, Ralph L.;Wen, Wei;Thalamuthu, Anbupalam;Armstrong, Nicola J.;Chong, Elizabeth;Schofield, Peter R.;Kwok, John B.;van der Grond, Jeroen;Stott, David J.;Ford, Ian;Jukema, J. Wouter;Vernooij, Meike W.;Hofman, Albert;Uitterlinden, André G.;van der Lugt, Aad;Wittfeld, Katharina;Grabe, Hans J.;Hosten, Norbert;von Sarnowski, Bettina;Völker, Uwe;Levi, Christopher;Jimenez-Conde, Jordi;Sharma, Pankaj;Sudlow, Cathie L. M.;Rosand, Jonathan;Woo, Daniel;Cole, John W.;Meschia, James F.;Slowik, Agnieszka;Thijs, Vincent;Lindgren, Arne;Melander, Olle;Grewal, Raji P.;Rundek, Tatjana;Rexrode, Kathy;Rothwell, Peter M.;Arnett, Donna K.;Jern, Christina;Johnson, Julie A.;Benavente, Oscar R.;Wasssertheil-Smoller, Sylvia;Lee, Jin-Moo;Wong, Quenna;Mitchell, Braxton D.;Rich, Stephen S.;McArdle, Patrick F.;Geerlings, Mirjam I.;van der Graaf, Yolanda;de Bakker, Paul I. W.;Asselbergs, Folkert W.;Srikanth, Velandai;Thomson, Russell;McWhirter, Rebekah;Moran, Chris;Callisaya, Michele;Phan, Thanh;Rutten-Jacobs, Loes C. A.;Bevan, Steve;Tzourio, Christophe;Mather, Karen A.;Sachdev, Perminder S.;van Duijn, Cornelia M.;Worrall, Bradford B.;Dichgans, Martin;Kittner, Steven J.;Markus, Hugh S.;Ikram, Mohammad A.;Fornage, Myriam;Launer, Lenore J.;Seshadri, Sudha;Longstreth, W. T.;Debette, Stéphanie;null, null;Almgren, Peter;Anderson, Christopher D.;Arnett, Donna K.;Attia, John;Ay, Hakan;Benavente, Oscar R.;Bevan, Steve;Brown, Robert D.;Bustamante, Mariana;Cheng, Yu-Ching;Cole, John W.;Cotlarciuc, Ioana;Cruchaga, Carlos;de Bakker, Paul IW.;Delavaran, Hossein;Dichgans, Martin;Engström, Gunnar;Fornage, Myriam;Grewal, Raji P.;Heitsch, Laura;Holliday, Elizabeth;Ibanez, Laure;Ilinca, Andreea;Irvin, Marguerite R.;Jackson, Rebecca D.;Jern, Christina;Jimenez-Conde, Jordi;Johnson, Julie A.;Jood, Katarina;Kissela, Brett M.;Kittner, Steven J.;Kleindorfer, Dawn O.;Labovitz, Daniel;Laurie, Cathy C.;Lee, Jin-Moo;Lemmens, Robin;Levi, Christopher;Li, Linxin;Lindgren, Arne G.;Maguire, Jane;Markus, Hugh S.;McArdle, Patrick F.;Melander, Olle;Meschia, James F.;Mitchell, Braxton D.;Müller-Nurasyid, Martina;Norrving, Bo;Peddareddygari, Leema Reddy;Pera, Joanna;Pulit, Sara L.;Rexrode, Kathryn;Ribasés, Marta;Roquer, Jaume;Rost, Natalia S.;Rothwell, Peter M.;Rundek, Tatjana;Sacco, Ralph L.;Schmidt, Reinhold;Sharma, Pankaj;Slowik, Agnieszka;Soriano-Tárraga, Carolina;Stanne, Tara;Stauch, Konstantin;Stine, O C.;Sudlow, Cathie LM.;Thijs, Vincent N. 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Jern;Keat Wei Loo;Gabriel Rinkel;Paulo Franca;Iscia Cendes;Caty Carrera;Israel Fernandez-Cadenas;Joan Montaner;Helen Kim;Mayowa Owolabi;Reecha Sofat;Mark Bakker;Ynte Ruigrok;Allard Hauer;Sara L Pulit;Sander W van der Laan;Ryan Irvin;Murali Sargurupremraj;Alessandro Pezzini;Foad Abd-Allah;David Liebeskind;Matthew Traylor;Rhea Tan;John Danesh;Loes Rutten-Jacobs;Amanda Donatti;Wagner Avelar;Joseph Broderick;Daniel Woo;Cathie Sudlow;Kristiina Rannikmae;Caitrin Wheeler McDonough;Tom van Agtmael;Matthew Walters;Martin Söderholm;Erik Lorentzen;Sandra Olsson;Tara Stanne;Martina Olsson;Rufus Akinyemi;Ioana Cotlatciuc;Patrick McArdle;Tushar Dave;Steven Kittner;John Attia;James E Faber;Iona Millwood;Elsa Valdés Márquez;Michelangelo Mancuso;Riina Vibo;Janika Korv;Jane Maguire;Myriam Fornage;Jennifer Majersik;Adam DeHavenon;Matthew Alexander;Michele Sale;Andrew Southerland;Debra Owens;Bruce Psaty;W T Longstreth Jr;Stacey Quintero Wolfe;Carl Langefeld;Carlos Cruchaga;Jan Konrad;Kevin Sheth;Guido Falcone;Kathleen Donahue;Alexis N Simpkins;Tan Wei Liang Byorn;Bernard Chan;Phil Clatworthy;Jose Florez;Eric Harshfield;Atsushi Hozawa;Chung Hsu;Chaur-Jong Hu;Laure Ibanez;Masafumi Ihara;Marcos Lange;Soo Ji Lee;I-Hui Lee;Patricia Musolino;Hirofumi Nakatomi;Kwang-Yeol Park;Stephen S Rich;Chris Riley;Joohon Sung;Hideaki Suzuki;Katie Vo;Kazuo Washida;Laura Garcia Ibenez;Agnieszka Slowik;Albert Hofman;Ale Algra;Alex P Reiner;Alexander S F Doney;Andreas Gschwendtner;Andreea Ilinca;Anne-Katrin Giese;Arne Lindgren;Astrid M Vicente;Bo Norrving;Børge G Nordestgaard;Braxton D Mitchell;Bradford B Worrall;Bruce M Psaty;Cara L Carty;Cathie Sudlow;Christopher D Anderson;Christopher Levi;Claudia L Satizabal;Colin N A Palmer;Dale M Gamble;Daniel Woo;Danish Saleheen;E Bernd Ringelstein;Einar Valdimarsson;Elizabeth Holliday;Gail Davies;Ganesh Chauhan;Gerard Pasterkamp;Giorgio Boncoraglio;Gregor Kuhlenbäumer;Gudmar Thorleifsson;Guido J Falcone;Guillame Pare;Helena Schmidt;Hossein Delavaran;Hugh S 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Uda;Eric Boerwinkle;Norman Klopp;Helena Schmidt;James F Wilson;Jorma Viikari;Wolfgang Koenig;Stefan Blankenberg;Anne B Newman;Jacqueline Witteman;Gerardo Heiss;Cornelia van Duijn;Angelo Scuteri;Georg Homuth;Braxton D Mitchell;Vilmundur Gudnason;Christopher J O'Donnell
2019-01-01
Abstract
ObjectiveTo explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts.MethodsWe performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors and their genetic risk scores (GRS) with MRI-defined BI and a subset of BI, namely, small subcortical BI (SSBI), in 18 population-based cohorts (n = 20,949) from 5 ethnicities (3,726 with BI, 2,021 with SSBI). Top loci were followed up in 7 population-based cohorts (n = 6,862; 1,483 with BI, 630 with SBBI), and we tested associations with related phenotypes including ischemic stroke and pathologically defined BI.ResultsThe mean prevalence was 17.7% for BI and 10.5% for SSBI, steeply rising after age 65. Two loci showed genome-wide significant association with BI: FBN2, p = 1.77 x 10(-8); and LINC00539/ZDHHC20, p = 5.82 x 10(-9). Both have been associated with blood pressure (BP)-related phenotypes, but did not replicate in the smaller follow-up sample or show associations with related phenotypes. Age- and sex-adjusted associations with BI and SSBI were observed for BP traits (p value for BI, p([BI]) = 9.38 x 10(-25); p([SSBI]) = 5.23 x 10(-14) for hypertension), smoking (p([BI]) = 4.4 x 10(-10); p([SSBI]) = 1.2 x 10(-4)), diabetes (p([BI]) = 1.7 x 10(-8); p([SSBI]) = 2.8 x 10(-3)), previous cardiovascular disease (p([BI]) = 1.0 x 10(-18); p([SSBI]) = 2.3 x 10(-7)), stroke (p([BI]) = 3.9 x 10(-69); p([SSBI]) = 3.2 x 10(-24)), and MRI-defined white matter hyperintensity burden (p([BI]) = 1.43 x 10(-157); p([SSBI]) = 3.16 x 10(-106)), but not with body mass index or cholesterol. GRS of BP traits were associated with BI and SSBI (p 0.0022), without indication of directional pleiotropy.ConclusionIn this multiethnic GWAS meta-analysis, including over 20,000 population-based participants, we identified genetic risk loci for BI requiring validation once additional large datasets become available. High BP, including genetically determined, was the most significant modifiable, causal risk factor for BI.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2995637
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.