Introduction: Rare genitourinary tumors are lacking of randomized and observational data. We aimed to describe the clinical characteristics and outcomes of patients with collecting duct carcinoma (CDC) through the Meet-URO 23/I-RARE database. Materials and methods: We performed a multicentric retrospective-prospective study within the Meet-URO network, enrolling patients from March 2021 (retrospectively up from 2011) until March 2023. The primary objective was to describe the clinical characteristics of patients with CDC, the secondary objectives were to assess the oncological outcomes in terms of relapse-free survival (RFS), progression-free survival (PFS), overall survival (OS) and objective response rate (ORR) to treatment. Results: 37 patients with CDC were enrolled. Four patients underwent only surgery, 33 received first-line systemic therapy. Median OS was 22.1 months (95% CI, 8.9-31.9). Median RFS for patients with localized disease at onset (n = 30) was 3.7 months (95% CI, 1.9-12.8), median PFS for first-line treatment was 3.3 months (95% CI, 2.7-9.9), with an ORR of 27%. Female sex and good performance status (PS) were associated with longer PFS (P = .072 and P < .01, respectively) and OS (P = .030 and P = .141, respectively). Conclusions: Patients with CDC had dismal prognosis, with scarce benefit from the available treatments. Female sex and good PS seemed to be associated with better prognosis.

Italian Registry on Rare Urological Tumors (Meet-URO-23): The First Analysis on Collecting Duct Carcinoma of the Kidney / Giudice, Giulia Claire; Maruzzo, Marco; Verzoni, Elena; Procopio, Giuseppe; Bimbatti, Davide; Sepe, Pierangela; Maines, Francesca; Grillone, Francesco; Cavo, Alessia; Santoni, Matteo; Cordua, Nadia; Pecoraro, Giovanna; Prati, Veronica; Napoli, Marilena Di; Ollari, Eli; Caruso, Giuseppe; Simoni, Nicola; Campobasso, Davide; Buti, Sebastiano. - In: CLINICAL GENITOURINARY CANCER. - ISSN 1558-7673. - (2024). [10.1016/j.clgc.2024.102186]

Italian Registry on Rare Urological Tumors (Meet-URO-23): The First Analysis on Collecting Duct Carcinoma of the Kidney

Giudice, Giulia Claire
Writing – Original Draft Preparation
;
Caruso, Giuseppe
Investigation
;
Simoni, Nicola
Investigation
;
Buti, Sebastiano
Conceptualization
2024-01-01

Abstract

Introduction: Rare genitourinary tumors are lacking of randomized and observational data. We aimed to describe the clinical characteristics and outcomes of patients with collecting duct carcinoma (CDC) through the Meet-URO 23/I-RARE database. Materials and methods: We performed a multicentric retrospective-prospective study within the Meet-URO network, enrolling patients from March 2021 (retrospectively up from 2011) until March 2023. The primary objective was to describe the clinical characteristics of patients with CDC, the secondary objectives were to assess the oncological outcomes in terms of relapse-free survival (RFS), progression-free survival (PFS), overall survival (OS) and objective response rate (ORR) to treatment. Results: 37 patients with CDC were enrolled. Four patients underwent only surgery, 33 received first-line systemic therapy. Median OS was 22.1 months (95% CI, 8.9-31.9). Median RFS for patients with localized disease at onset (n = 30) was 3.7 months (95% CI, 1.9-12.8), median PFS for first-line treatment was 3.3 months (95% CI, 2.7-9.9), with an ORR of 27%. Female sex and good performance status (PS) were associated with longer PFS (P = .072 and P < .01, respectively) and OS (P = .030 and P = .141, respectively). Conclusions: Patients with CDC had dismal prognosis, with scarce benefit from the available treatments. Female sex and good PS seemed to be associated with better prognosis.
2024
Italian Registry on Rare Urological Tumors (Meet-URO-23): The First Analysis on Collecting Duct Carcinoma of the Kidney / Giudice, Giulia Claire; Maruzzo, Marco; Verzoni, Elena; Procopio, Giuseppe; Bimbatti, Davide; Sepe, Pierangela; Maines, Francesca; Grillone, Francesco; Cavo, Alessia; Santoni, Matteo; Cordua, Nadia; Pecoraro, Giovanna; Prati, Veronica; Napoli, Marilena Di; Ollari, Eli; Caruso, Giuseppe; Simoni, Nicola; Campobasso, Davide; Buti, Sebastiano. - In: CLINICAL GENITOURINARY CANCER. - ISSN 1558-7673. - (2024). [10.1016/j.clgc.2024.102186]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2994673
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