Aim: To investigate the different impact of each component of lipid profile in advanced cancer patients treated with immune checkpoints inhibitors (ICIs) according to neutrophil-to-lymphocyte ratio (NLR) value. Methods: We retrospectively collected total cholesterol (TC), triglycerides (TGs), low-density lipoproteins (LDL), high-density lipoproteins (HDL). Results: 407 patients were enrolled. In NLR <4 subgroup, TGs <150 mg/dl led to longer PFS (p = 0.01) and OS (p = 0.02) compared with TGs ≥150 mg/dl; LDL <100 mg/dl led to longer PFS (p = 0.004) and OS (p = 0.007) compared with LDL ≥100 mg/dl. In NLR ≥4 subgroup, TC >200 mg/dl led to longer PFS (p = 0.008) and OS (p = 0.004) compared with TC <200 mg/dl. Conclusion: We showed a distinct prognostic impact of lipid profile according to NLR.
Differential impact of lipid profile according to neutrophil-to-lymphocyte ratio status in patients with advanced cancer treated with immunotherapy / Perrone, Fabiana; Pecci, Federica; Maffezzoli, Michele; Giudice, Giulia Claire; Cognigni, Valeria; Mazzaschi, Giulia; Cantini, Luca; Santamaria, Luca; Paoloni, Francesco; Bruno Rocchi, Marco Luigi; Coriano', Matilde; Acunzo, Alessandro; Quaini, Federico; Tiseo, Marcello; Kamal, Saini S; Berardi, Rossana; Buti, Sebastiano. - In: IMMUNOTHERAPY. - ISSN 1750-743X. - (2024), pp. 1-10. [10.1080/1750743x.2024.2377953]
Differential impact of lipid profile according to neutrophil-to-lymphocyte ratio status in patients with advanced cancer treated with immunotherapy
Pecci, Federica
Project Administration
;Maffezzoli, MicheleInvestigation
;Giudice, Giulia ClaireInvestigation
;Mazzaschi, GiuliaInvestigation
;Coriano', MatildeInvestigation
;Acunzo, AlessandroInvestigation
;Quaini, FedericoInvestigation
;Tiseo, MarcelloInvestigation
;Buti, SebastianoConceptualization
2024-01-01
Abstract
Aim: To investigate the different impact of each component of lipid profile in advanced cancer patients treated with immune checkpoints inhibitors (ICIs) according to neutrophil-to-lymphocyte ratio (NLR) value. Methods: We retrospectively collected total cholesterol (TC), triglycerides (TGs), low-density lipoproteins (LDL), high-density lipoproteins (HDL). Results: 407 patients were enrolled. In NLR <4 subgroup, TGs <150 mg/dl led to longer PFS (p = 0.01) and OS (p = 0.02) compared with TGs ≥150 mg/dl; LDL <100 mg/dl led to longer PFS (p = 0.004) and OS (p = 0.007) compared with LDL ≥100 mg/dl. In NLR ≥4 subgroup, TC >200 mg/dl led to longer PFS (p = 0.008) and OS (p = 0.004) compared with TC <200 mg/dl. Conclusion: We showed a distinct prognostic impact of lipid profile according to NLR.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
