Pre-eclampsia and fetal growth restriction (FGR) have been long related to primary placental dysfunction, caused by abnormal trophoblast invasion. Nevertheless, emerging evidence has led to a new hypothesis for the origin of pre-eclampsia and FGR. Suboptimal maternal cardiovascular adaptation has been shown to result in uteroplacental hypoperfusion, ultimately leading to placental hypoxic damage with secondary dysfunction. In this review, we summarize current evidence on maternal cardiac hemodynamics in FGR and pre-eclampsia. We also discuss the different approaches for antihypertensive treatment according to the hemodynamic phenotype observed in pre-eclampsia and FGR.
An update on maternal cardiac hemodynamics in fetal growth restriction and pre-eclampsia / Dall'Asta, A.; Minopoli, M.; Ramirez Zegarra, R.; Di Pasquo, E.; Ghi, T.. - In: JOURNAL OF CLINICAL ULTRASOUND. - ISSN 0091-2751. - 51:2(2023), pp. 265-272. [10.1002/jcu.23392]
An update on maternal cardiac hemodynamics in fetal growth restriction and pre-eclampsia
Dall'Asta A.
Conceptualization
;Minopoli M.Membro del Collaboration Group
;Ramirez Zegarra R.Membro del Collaboration Group
;Ghi T.Supervision
2023-01-01
Abstract
Pre-eclampsia and fetal growth restriction (FGR) have been long related to primary placental dysfunction, caused by abnormal trophoblast invasion. Nevertheless, emerging evidence has led to a new hypothesis for the origin of pre-eclampsia and FGR. Suboptimal maternal cardiovascular adaptation has been shown to result in uteroplacental hypoperfusion, ultimately leading to placental hypoxic damage with secondary dysfunction. In this review, we summarize current evidence on maternal cardiac hemodynamics in FGR and pre-eclampsia. We also discuss the different approaches for antihypertensive treatment according to the hemodynamic phenotype observed in pre-eclampsia and FGR.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
