Iron-catalyzed C-H activation has recently emerged as an increasingly powerful synthetic method for the step- and atom- economical direct C-H functionalizations of otherwise inert C-H bonds. Iron's low-cost and toxicity along with its catalytic versatility have encouraged the scientific community to elect this metal for the development of new C-H activation methodologies. Within this review, we aim to present a collection of the most recent examples of iron-catalyzed C-H functionalizations with a particular emphasis on modern synthetic strategies and mechanistic aspects.Iron-catalyzed C-H activations represent one of the most promising techniques in organic chemistry in terms of sustainability. Herein, modern synthetic strategies will be discussed including chelate-assisted functionalizations, bimetallic activations, ligand design for reactions of unsaturated molecules, isotopic labelling and finally photo-assisted transformations.image
Modern Organometallic C−H Functionalizations with Earth‐Abundant Iron Catalysts: An Update / Cattani, Silvia; Cera, Gianpiero. - In: CHEMISTRY - AN ASIAN JOURNAL. - ISSN 1861-4728. - 19:1(2024). [10.1002/asia.202300897]
Modern Organometallic C−H Functionalizations with Earth‐Abundant Iron Catalysts: An Update
Cattani, Silvia;Cera, Gianpiero
2024-01-01
Abstract
Iron-catalyzed C-H activation has recently emerged as an increasingly powerful synthetic method for the step- and atom- economical direct C-H functionalizations of otherwise inert C-H bonds. Iron's low-cost and toxicity along with its catalytic versatility have encouraged the scientific community to elect this metal for the development of new C-H activation methodologies. Within this review, we aim to present a collection of the most recent examples of iron-catalyzed C-H functionalizations with a particular emphasis on modern synthetic strategies and mechanistic aspects.Iron-catalyzed C-H activations represent one of the most promising techniques in organic chemistry in terms of sustainability. Herein, modern synthetic strategies will be discussed including chelate-assisted functionalizations, bimetallic activations, ligand design for reactions of unsaturated molecules, isotopic labelling and finally photo-assisted transformations.imageI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.