A two-step protocol for the modular synthesis of β2- and α-quaternary β2,2-amino acid derivatives is reported. The key steps are a photocatalytic hydroalkylation reaction, followed by an oxidative functionalisation to access N-protected β-amino acids, esters, and amides. This strategy can be effectively scaled up via continuous-flow technology.

Modular synthesis of congested β-2,2-amino acids via the merger of photocatalysis and oxidative functionalisations / Anwar, Khadijah; Capaldo, Luca; Wan, Ting; Noël, Timothy; Gómez-Suárez, Adrián. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 60:11(2024), pp. 1456-1459. [10.1039/d3cc06172h]

Modular synthesis of congested β-2,2-amino acids via the merger of photocatalysis and oxidative functionalisations

Capaldo, Luca;
2024-01-01

Abstract

A two-step protocol for the modular synthesis of β2- and α-quaternary β2,2-amino acid derivatives is reported. The key steps are a photocatalytic hydroalkylation reaction, followed by an oxidative functionalisation to access N-protected β-amino acids, esters, and amides. This strategy can be effectively scaled up via continuous-flow technology.
2024
Modular synthesis of congested β-2,2-amino acids via the merger of photocatalysis and oxidative functionalisations / Anwar, Khadijah; Capaldo, Luca; Wan, Ting; Noël, Timothy; Gómez-Suárez, Adrián. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 60:11(2024), pp. 1456-1459. [10.1039/d3cc06172h]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2978915
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