Modular synthesis of congested β-2,2-amino acids via the merger of photocatalysis and oxidative functionalisations

: A two-step protocol for the modular synthesis of β2- and α-quaternary β2,2-amino acid derivatives is reported. The key steps are a photocatalytic hydroalkylation reaction, followed by an oxidative functionalisation to access N-protected β-amino acids, esters, and amides. This strategy can be effectively scaled up via continuous-flow technology.