: This study aims to estimate long-term survival, cancer prevalence, and several cure indicators for Italian women with gynaecological cancers. Thirty-one cancer registries, representing 47% of the Italian female population, were included. Mixture cure models were used to estimate Net Survival (NS), Cure Fraction, Time To Cure (5-year conditional NS>95%), Cure Prevalence (women who will not die of cancer), and Already Cured (living longer than Time to Cure). In 2018, 0.4% (121,704) of Italian women were alive after corpus uteri cancer, 0.2% (52,551) after cervical, and 0.2% (52,153) after ovarian cancer. More than 90% of patients with uterine cancers and 83% with ovarian cancer will not die from their neoplasm (Cure Prevalence). Women with gynaecological cancers have a residual excess risk of death <5% after 5 years since diagnosis. The Cure Fraction was 69% for corpus uteri, 32% for ovarian, and 58% for cervical cancer patients. Time To Cure was ≤10 years for women with gynaecological cancers aged <55 years. 74% of patients with cervical cancer, 63% with corpus uteri cancer, and 55% with ovarian cancer were Already Cured. These results will contribute to improving follow-up programs for women with gynaecological cancers and supporting efforts against discrimination of already cured ones.
Indicators of cure for women living after uterine and ovarian cancers: a population-based study / Giudici, Fabiola; De Paoli, Angela; Toffolutti, Federica; Guzzinati, Stefano; Francisci, Silvia; Bucchi, Lauro; Gatta, Gemma; Demuru, Elena; Mallone, Sandra; Cin, Antonella Dal; Caldarella, Adele; Cuccaro, Francesco; Migliore, Enrica; Gambino, Maria Letizia; Ravaioli, Alessandra; Puppo, Antonella; Ferrante, Margherita; Carrozzi, Giuliano; Stracci, Fabrizio; Musolino, Antonino; Gasparotti, Cinzia; Cavallo, Rossella; Mazzucco, Walter; Vitale, Maria Francesca; Cascone, Giuseppe; Ballotari, Paola; Ferretti, Stefano; Mangone, Lucia; Rizzello, Roberto Vito; Sampietro, Giuseppe; Mian, Michael; Boschetti, Lorenza; Galasso, Rocco; Bella, Francesca; Piras, Daniela; Sessa, Alessandra; Seghini, Pietro; Fanetti, Anna Clara; Pinna, Pasquala; De Angelis, Roberta; Serraino, Diego; Maso, Luigino Dal; working group, Airtum. - In: AMERICAN JOURNAL OF EPIDEMIOLOGY. - ISSN 0002-9262. - (2024). [10.1093/aje/kwae044]
Indicators of cure for women living after uterine and ovarian cancers: a population-based study
Musolino, Antonino;
2024-01-01
Abstract
: This study aims to estimate long-term survival, cancer prevalence, and several cure indicators for Italian women with gynaecological cancers. Thirty-one cancer registries, representing 47% of the Italian female population, were included. Mixture cure models were used to estimate Net Survival (NS), Cure Fraction, Time To Cure (5-year conditional NS>95%), Cure Prevalence (women who will not die of cancer), and Already Cured (living longer than Time to Cure). In 2018, 0.4% (121,704) of Italian women were alive after corpus uteri cancer, 0.2% (52,551) after cervical, and 0.2% (52,153) after ovarian cancer. More than 90% of patients with uterine cancers and 83% with ovarian cancer will not die from their neoplasm (Cure Prevalence). Women with gynaecological cancers have a residual excess risk of death <5% after 5 years since diagnosis. The Cure Fraction was 69% for corpus uteri, 32% for ovarian, and 58% for cervical cancer patients. Time To Cure was ≤10 years for women with gynaecological cancers aged <55 years. 74% of patients with cervical cancer, 63% with corpus uteri cancer, and 55% with ovarian cancer were Already Cured. These results will contribute to improving follow-up programs for women with gynaecological cancers and supporting efforts against discrimination of already cured ones.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
