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Methotrexate (MTX) is a key anchor drug for rheumatoid arthritis (RA) management. Fibrotic interstitial lung disease (ILD) is a common complication of RA. Whether MTX exposure increases the risk of ILD in patients with RA is disputed. We aimed to evaluate the association of prior MTX use with development of RA-ILD.

Methotrexate and rheumatoid arthritis associated interstitial lung disease / Juge, Pierre-Antoine; Lee, Joyce S; Lau, Jessica; Kawano-Dourado, Leticia; Rojas Serrano, Jorge; Sebastiani, Marco; Koduri, Gouri; Matteson, Eric; Bonfiglioli, Karina; Sawamura, Marcio; Kairalla, Ronaldo; Cavagna, Lorenzo; Bozzalla Cassione, Emanuele; Manfredi, Andreina; Mejia, Mayra; Rodríguez-Henriquez, Pedro; González-Pérez, Montserrat I; Falfán-Valencia, Ramcés; Buendia-Roldán, Ivette; Pérez-Rubio, Gloria; Ebstein, Esther; Gazal, Steven; Borie, Raphaël; Ottaviani, Sébastien; Kannengiesser, Caroline; Wallaert, Benoît; Uzunhan, Yurdagul; Nunes, Hilario; Valeyre, Dominique; Saidenberg-Kermanac'h, Nathalie; Boissier, Marie-Christophe; Wemeau-Stervinou, Lidwine; Flipo, René-Marc; Marchand-Adam, Sylvain; Richette, Pascal; Allanore, Yannick; Dromer, Claire; Truchetet, Marie-Elise; Richez, Christophe; Schaeverbeke, Thierry; Lioté, Huguette; Thabut, Gabriel; Deane, Kevin D; Solomon, Joshua; Doyle, Tracy; Ryu, Jay H; Rosas, Ivan; Holers, V Michael; Boileau, Catherine; Debray, Marie-Pierre; Porcher, Raphaël; Schwartz, David A; Vassallo, Robert; Crestani, Bruno; Dieudé, Philippe. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - 57:2(2020), pp. 1-9. [10.1183/13993003.00337-2020]

Methotrexate and rheumatoid arthritis associated interstitial lung disease

Sebastiani, Marco;
2020-01-01

Abstract

Methotrexate (MTX) is a key anchor drug for rheumatoid arthritis (RA) management. Fibrotic interstitial lung disease (ILD) is a common complication of RA. Whether MTX exposure increases the risk of ILD in patients with RA is disputed. We aimed to evaluate the association of prior MTX use with development of RA-ILD.
2020
Methotrexate and rheumatoid arthritis associated interstitial lung disease / Juge, Pierre-Antoine; Lee, Joyce S; Lau, Jessica; Kawano-Dourado, Leticia; Rojas Serrano, Jorge; Sebastiani, Marco; Koduri, Gouri; Matteson, Eric; Bonfiglioli, Karina; Sawamura, Marcio; Kairalla, Ronaldo; Cavagna, Lorenzo; Bozzalla Cassione, Emanuele; Manfredi, Andreina; Mejia, Mayra; Rodríguez-Henriquez, Pedro; González-Pérez, Montserrat I; Falfán-Valencia, Ramcés; Buendia-Roldán, Ivette; Pérez-Rubio, Gloria; Ebstein, Esther; Gazal, Steven; Borie, Raphaël; Ottaviani, Sébastien; Kannengiesser, Caroline; Wallaert, Benoît; Uzunhan, Yurdagul; Nunes, Hilario; Valeyre, Dominique; Saidenberg-Kermanac'h, Nathalie; Boissier, Marie-Christophe; Wemeau-Stervinou, Lidwine; Flipo, René-Marc; Marchand-Adam, Sylvain; Richette, Pascal; Allanore, Yannick; Dromer, Claire; Truchetet, Marie-Elise; Richez, Christophe; Schaeverbeke, Thierry; Lioté, Huguette; Thabut, Gabriel; Deane, Kevin D; Solomon, Joshua; Doyle, Tracy; Ryu, Jay H; Rosas, Ivan; Holers, V Michael; Boileau, Catherine; Debray, Marie-Pierre; Porcher, Raphaël; Schwartz, David A; Vassallo, Robert; Crestani, Bruno; Dieudé, Philippe. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - 57:2(2020), pp. 1-9. [10.1183/13993003.00337-2020]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2977562
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