The mortality of hip fracture (HF) patients is increased by concomitant COVID-19; however, evidence is limited to only short follow-up. A retrospective matched case–control study was designed with the aim to report the 90-day mortality and determine the hazard ratio (HR) of concomitant HF and COVID-19 infection. Cases were patients hospitalized for HF and diagnosed with COVID-19. Controls were patients hospitalized for HF not meeting the criteria for COVID-19 diagnosis and were individually matched with each case through a case–control (1:3) matching algorithm. A total of 89 HF patients were treated during the study period, and 14 of them were diagnosed as COVID-19 positive (overall 15.7%). Patients’ demographic, clinical, and surgical characteristics were similar between case and control groups. At 90 days after surgery, 5 deaths were registered among the 14 COVID-19 cases (35.7%) and 4 among the 42 HF controls (9.5%). COVID-19-positive cases had a higher risk of mortality at 30 days (HR = 4.51; p = 0.0490) and 90 days (HR = 4.50; p = 0.025) with respect to controls. Patients with concomitant HF and COVID-19 exhibit high perioperative mortality, which reaches a plateau of nearly 30–35% after 30 to 45 days and is stable up to 90 days. The mortality risk is more than four-fold higher in patients with COVID-19.

Higher 90-day mortality after surgery for hip fractures in patients with covid-19: A case–control study from a single center in italy / Grassi, A.; Andriolo, L.; Golinelli, D.; Tedesco, D.; Rosa, S.; Gramegna, P.; Ciaffi, J.; Meliconi, R.; Landini, M. P.; Filardo, G.; Fantini, M. P.; Zaffagnini, S.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 18:10(2021), pp. 5205.1-5205.13. [10.3390/ijerph18105205]

Higher 90-day mortality after surgery for hip fractures in patients with covid-19: A case–control study from a single center in italy

Tedesco D.;Landini M. P.;
2021-01-01

Abstract

The mortality of hip fracture (HF) patients is increased by concomitant COVID-19; however, evidence is limited to only short follow-up. A retrospective matched case–control study was designed with the aim to report the 90-day mortality and determine the hazard ratio (HR) of concomitant HF and COVID-19 infection. Cases were patients hospitalized for HF and diagnosed with COVID-19. Controls were patients hospitalized for HF not meeting the criteria for COVID-19 diagnosis and were individually matched with each case through a case–control (1:3) matching algorithm. A total of 89 HF patients were treated during the study period, and 14 of them were diagnosed as COVID-19 positive (overall 15.7%). Patients’ demographic, clinical, and surgical characteristics were similar between case and control groups. At 90 days after surgery, 5 deaths were registered among the 14 COVID-19 cases (35.7%) and 4 among the 42 HF controls (9.5%). COVID-19-positive cases had a higher risk of mortality at 30 days (HR = 4.51; p = 0.0490) and 90 days (HR = 4.50; p = 0.025) with respect to controls. Patients with concomitant HF and COVID-19 exhibit high perioperative mortality, which reaches a plateau of nearly 30–35% after 30 to 45 days and is stable up to 90 days. The mortality risk is more than four-fold higher in patients with COVID-19.
2021
Higher 90-day mortality after surgery for hip fractures in patients with covid-19: A case–control study from a single center in italy / Grassi, A.; Andriolo, L.; Golinelli, D.; Tedesco, D.; Rosa, S.; Gramegna, P.; Ciaffi, J.; Meliconi, R.; Landini, M. P.; Filardo, G.; Fantini, M. P.; Zaffagnini, S.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 18:10(2021), pp. 5205.1-5205.13. [10.3390/ijerph18105205]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2970431
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