Background Oral lichen planus (OLP) is an immune-mediated inflammatory chronic disease of the oral mucosa, with different patterns of clinical manifestations which range from keratotic manifestations (K-OLP) to predominantly non-keratotic lesions (nK-OLP). The aim of the study was to analyze the differences in the clinical, psychological profile and symptoms between Italian patients of the North and Central-South with K-OLP and nK-OLP. Methods 270 K-OLP and 270 nK-OLP patients were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS) were administered. Results The Central-South K-OLP (CS-K-OLP) patients reported a higher frequency of pain/burning compared with the K-OLP patients of the North (N-K-OLP) with higher scores in the NRS and T-PRI (p value < 0.001**). The CS-K-OLP and the CS-nK-OLP patients showed higher scores in the HAM-D, HAM-A, PSQI and ESS compared with the Northern patients (p value < 0.001**). Multivariate logistic regression revealed that the NRS and T-PRI showed the greatest increase in the R2 value for the CS-K-OLP (DR2 = 9.6%; p value < 0.001**; DR2 = 9.7% p value < 0.001**; respectively) and that the oral symptoms (globus, itching and intraoral foreign body sensation) and PSQI showed the greatest increase in the R2 value for the CS-nK-OLP (DR2 = 5.6%; p value < 0.001**; DR2 = 4.5% p value < 0.001** respectively). Conclusions Pain and mood disorders are predominant in patients with OLP in the Central-South of Italy. Clinicians should consider that the geographical living area may explain the differences in oral symptoms and psychological profile in OLP.

Where do you live? North versus Central-South differences in relation to Italian patients with oral lichen planus: a cross-sectional study from the SIPMO (Italian Society of Oral Pathology and Medicine) / Adamo, Daniela; Calabria, Elena; Canfora, Federica; Coppola, Noemi; Lo Muzio, Lorenzo; Spirito, Francesca; Giuliani, Michele; Azzi, Lorenzo; Maurino, Vittorio; Colella, Giuseppe; Colella, Chiara; Montebugnoli, Lucio; Gissi, Davide Bartolomeo; Gabriele, Mario; Nisi, Marco; Sardella, Andrea; Lodi, Giovanni; Varoni, Elena Maria; Giudice, Amerigo; Antonelli, Alessandro; Arduino, Paolo Giacomo; Gambino, Alessio; Vescovi, Paolo; Majorana, Alessandra; Bardellini, Elena; Campisi, Giuseppina; Panzarella, Vera; Spadari, Francesco; Garagiola, Umberto; Pentenero, Monica; Sutera, Samuele; Biasotto, Matteo; Ottaviani, Giulia; Gobbo, Margherita; Guarda Nardini, Luca; Romeo, Umberto; Tenore, Gianluca; Serpico, Rosario; Lucchese, Alberta; Lajolo, Carlo; Rupe, Cosimo; Aria, Massimo; D'Aniello, Luca; Mignogna, Michele Davide. - In: BMC ORAL HEALTH. - ISSN 1472-6831. - 22:1(2022), p. 184. [10.1186/s12903-022-02181-7]

Where do you live? North versus Central-South differences in relation to Italian patients with oral lichen planus: a cross-sectional study from the SIPMO (Italian Society of Oral Pathology and Medicine)

Lo Muzio, Lorenzo;Montebugnoli, Lucio;Vescovi, Paolo;Pentenero, Monica;
2022-01-01

Abstract

Background Oral lichen planus (OLP) is an immune-mediated inflammatory chronic disease of the oral mucosa, with different patterns of clinical manifestations which range from keratotic manifestations (K-OLP) to predominantly non-keratotic lesions (nK-OLP). The aim of the study was to analyze the differences in the clinical, psychological profile and symptoms between Italian patients of the North and Central-South with K-OLP and nK-OLP. Methods 270 K-OLP and 270 nK-OLP patients were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS) were administered. Results The Central-South K-OLP (CS-K-OLP) patients reported a higher frequency of pain/burning compared with the K-OLP patients of the North (N-K-OLP) with higher scores in the NRS and T-PRI (p value < 0.001**). The CS-K-OLP and the CS-nK-OLP patients showed higher scores in the HAM-D, HAM-A, PSQI and ESS compared with the Northern patients (p value < 0.001**). Multivariate logistic regression revealed that the NRS and T-PRI showed the greatest increase in the R2 value for the CS-K-OLP (DR2 = 9.6%; p value < 0.001**; DR2 = 9.7% p value < 0.001**; respectively) and that the oral symptoms (globus, itching and intraoral foreign body sensation) and PSQI showed the greatest increase in the R2 value for the CS-nK-OLP (DR2 = 5.6%; p value < 0.001**; DR2 = 4.5% p value < 0.001** respectively). Conclusions Pain and mood disorders are predominant in patients with OLP in the Central-South of Italy. Clinicians should consider that the geographical living area may explain the differences in oral symptoms and psychological profile in OLP.
2022
Where do you live? North versus Central-South differences in relation to Italian patients with oral lichen planus: a cross-sectional study from the SIPMO (Italian Society of Oral Pathology and Medicine) / Adamo, Daniela; Calabria, Elena; Canfora, Federica; Coppola, Noemi; Lo Muzio, Lorenzo; Spirito, Francesca; Giuliani, Michele; Azzi, Lorenzo; Maurino, Vittorio; Colella, Giuseppe; Colella, Chiara; Montebugnoli, Lucio; Gissi, Davide Bartolomeo; Gabriele, Mario; Nisi, Marco; Sardella, Andrea; Lodi, Giovanni; Varoni, Elena Maria; Giudice, Amerigo; Antonelli, Alessandro; Arduino, Paolo Giacomo; Gambino, Alessio; Vescovi, Paolo; Majorana, Alessandra; Bardellini, Elena; Campisi, Giuseppina; Panzarella, Vera; Spadari, Francesco; Garagiola, Umberto; Pentenero, Monica; Sutera, Samuele; Biasotto, Matteo; Ottaviani, Giulia; Gobbo, Margherita; Guarda Nardini, Luca; Romeo, Umberto; Tenore, Gianluca; Serpico, Rosario; Lucchese, Alberta; Lajolo, Carlo; Rupe, Cosimo; Aria, Massimo; D'Aniello, Luca; Mignogna, Michele Davide. - In: BMC ORAL HEALTH. - ISSN 1472-6831. - 22:1(2022), p. 184. [10.1186/s12903-022-02181-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2968455
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