Background: Cerebral venous thrombosis (CVT) is an uncommon cause of stroke in young adults. We aimed to determine the impact of age, gender and risk factors (including sex-specific) on CVT onset. Methods: We used data from the BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis), a multicentre multinational prospective observational study on CVT. Composite factors analysis (CFA) was performed to determine the impact on the age of CVT onset in males and females. Results: A total of 1309 CVT patients (75.3% females) aged > 18 years were recruited. The overall median (IQR-interquartile range) age for males and females was 46 (35-58) years and 37 (28-47) years (p < 0.001), respectively. However, the presence of antibiotic-requiring sepsis (p = 0.03, 95% CI 27-47 years) among males and gender-specific risk factors like pregnancy (p < 0.001, 95% CI 29-34 years), puerperium (p < 0.001, 95% CI 26-34 years) and oral contraceptive use (p < 0.001, 95% CI 33-36 years) were significantly associated with earlier onset of CVT among females. CFA demonstrated a significantly earlier onset of CVT in females, similar to 12 years younger, in those with multiple (> 1) compared to '0' risk factors (p < 0.001, 95% CI 32-35 years). Conclusions: Women suffer CVT 9 years earlier in comparison to men. Female patients with multiple (> 1) risk factors suffer CVT similar to 12 years earlier compared to those with no identifiable risk factors.

Age of onset of cerebral venous thrombosis: the BEAST study / Ranjan, Redoy; Ken-Dror, Gie; Martinelli, Ida; Grandone, Elvira; Hiltunen, Sini; Lindgren, Erik; Margaglione, Maurizio; Le Cam Duchez, Veronique; Bagan Triquenot, Aude; Zedde, Marialuisa; Mancuso, Michelangelo; Ruigrok, Ynte M; Worrall, Brad; Majersik, Jennifer J; Putaala, Jukka; Haapaniemi, Elena; Zuurbier, Susanna M; Brouwer, Matthijs C; Passamonti, Serena M; Abbattista, Maria; Bucciarelli, Paolo; Lemmens, Robin; Pappalardo, Emanuela; Costa, Paolo; Colombi, Marina; Aguiar de Sousa, Diana; Rodrigues, Sofia; Canhao, Patrícia; Tkach, Aleksander; Santacroce, Rosa; Favuzzi, Giovanni; Arauz, Antonio; Colaizzo, Donatella; Spengos, Kostas; Hodge, Amanda; Ditta, Reina; Han, Thang S; Pezzini, Alessandro; Coutinho, Jonathan M; Thijs, Vincent; Jood, Katarina; Tatlisumak, Turgut; Ferro, José M; Sharma, Pankaj. - In: EUROPEAN STROKE JOURNAL. - ISSN 2396-9881. - 8:1(2023), pp. 344-350. [10.1177/23969873221148267]

Age of onset of cerebral venous thrombosis: the BEAST study

Pezzini, Alessandro;
2023-01-01

Abstract

Background: Cerebral venous thrombosis (CVT) is an uncommon cause of stroke in young adults. We aimed to determine the impact of age, gender and risk factors (including sex-specific) on CVT onset. Methods: We used data from the BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis), a multicentre multinational prospective observational study on CVT. Composite factors analysis (CFA) was performed to determine the impact on the age of CVT onset in males and females. Results: A total of 1309 CVT patients (75.3% females) aged > 18 years were recruited. The overall median (IQR-interquartile range) age for males and females was 46 (35-58) years and 37 (28-47) years (p < 0.001), respectively. However, the presence of antibiotic-requiring sepsis (p = 0.03, 95% CI 27-47 years) among males and gender-specific risk factors like pregnancy (p < 0.001, 95% CI 29-34 years), puerperium (p < 0.001, 95% CI 26-34 years) and oral contraceptive use (p < 0.001, 95% CI 33-36 years) were significantly associated with earlier onset of CVT among females. CFA demonstrated a significantly earlier onset of CVT in females, similar to 12 years younger, in those with multiple (> 1) compared to '0' risk factors (p < 0.001, 95% CI 32-35 years). Conclusions: Women suffer CVT 9 years earlier in comparison to men. Female patients with multiple (> 1) risk factors suffer CVT similar to 12 years earlier compared to those with no identifiable risk factors.
2023
Age of onset of cerebral venous thrombosis: the BEAST study / Ranjan, Redoy; Ken-Dror, Gie; Martinelli, Ida; Grandone, Elvira; Hiltunen, Sini; Lindgren, Erik; Margaglione, Maurizio; Le Cam Duchez, Veronique; Bagan Triquenot, Aude; Zedde, Marialuisa; Mancuso, Michelangelo; Ruigrok, Ynte M; Worrall, Brad; Majersik, Jennifer J; Putaala, Jukka; Haapaniemi, Elena; Zuurbier, Susanna M; Brouwer, Matthijs C; Passamonti, Serena M; Abbattista, Maria; Bucciarelli, Paolo; Lemmens, Robin; Pappalardo, Emanuela; Costa, Paolo; Colombi, Marina; Aguiar de Sousa, Diana; Rodrigues, Sofia; Canhao, Patrícia; Tkach, Aleksander; Santacroce, Rosa; Favuzzi, Giovanni; Arauz, Antonio; Colaizzo, Donatella; Spengos, Kostas; Hodge, Amanda; Ditta, Reina; Han, Thang S; Pezzini, Alessandro; Coutinho, Jonathan M; Thijs, Vincent; Jood, Katarina; Tatlisumak, Turgut; Ferro, José M; Sharma, Pankaj. - In: EUROPEAN STROKE JOURNAL. - ISSN 2396-9881. - 8:1(2023), pp. 344-350. [10.1177/23969873221148267]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2964555
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