Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. After a two-phase internal review process, a final list of 98 research topics was scored by 48 experts. Patients with pre-existing or post-COVID-19 airways disease contributed to the exercise by weighting selected criteria. The highest-ranked research idea focused on investigation of the relationship between prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge in patients with and without pre-existing airways disease. High priority was also assigned to comparisons of the prevalence and severity of post-COVID-19 fatigue, sarcopenia, anxiety, depression, and risk of future cardiovascular complications in patients with and without pre-existing airways disease. Our approach has enabled development of a set of priorities that could inform future research studies and funding decisions. This prioritisation process could also be adapted to other, non-respiratory aspects of long COVID.

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease / Adeloye, Davies; Elneima, Omer; Daines, Luke; Poinasamy, Krisnah; Quint, Jennifer K; Walker, Samantha; Brightling, Chris E; Siddiqui, Salman; Hurst, John R; Chalmers, James D; Pfeffer, Paul E; Novotny, Petr; Drake, Thomas M; Heaney, Liam G; Rudan, Igor; Sheikh, Aziz; De Soyza, Anthony; Caramori, Gaetano. - In: THE LANCET RESPIRATORY MEDICINE. - ISSN 2213-2600. - 9:12(2021), pp. 1467-1478. [10.1016/S2213-2600(21)00286-1]

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease

Caramori, Gaetano
2021-01-01

Abstract

Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. After a two-phase internal review process, a final list of 98 research topics was scored by 48 experts. Patients with pre-existing or post-COVID-19 airways disease contributed to the exercise by weighting selected criteria. The highest-ranked research idea focused on investigation of the relationship between prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge in patients with and without pre-existing airways disease. High priority was also assigned to comparisons of the prevalence and severity of post-COVID-19 fatigue, sarcopenia, anxiety, depression, and risk of future cardiovascular complications in patients with and without pre-existing airways disease. Our approach has enabled development of a set of priorities that could inform future research studies and funding decisions. This prioritisation process could also be adapted to other, non-respiratory aspects of long COVID.
2021
The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease / Adeloye, Davies; Elneima, Omer; Daines, Luke; Poinasamy, Krisnah; Quint, Jennifer K; Walker, Samantha; Brightling, Chris E; Siddiqui, Salman; Hurst, John R; Chalmers, James D; Pfeffer, Paul E; Novotny, Petr; Drake, Thomas M; Heaney, Liam G; Rudan, Igor; Sheikh, Aziz; De Soyza, Anthony; Caramori, Gaetano. - In: THE LANCET RESPIRATORY MEDICINE. - ISSN 2213-2600. - 9:12(2021), pp. 1467-1478. [10.1016/S2213-2600(21)00286-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2964166
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