Inflammation is a central feature of asthma and chronic obstructive pulmonary disease (COPD). Despite recent advances in the knowledge of the pathogenesis of asthma and COPD, much more research on the molecular mechanisms of asthma and COPD are needed to aid the logical development of new therapies for these common and important diseases, particularly in COPD where no new effective treatments currently exist. In the future the role of the activation/repression of different transcription factors and the genetic regulation of their expression in asthma and COPD may be an increasingly important aspect of research, as this may be one of the critical mechanisms regulating the expression of different clinical phenotypes and their responsiveness to therapy, particularly to anti-inflammatory drugs.

Transcription inhibitors and inflammatory cell activity / Caramori, G.; Coppolino, I.; Cannavo, M. F.; Nucera, F.; Proietto, A.; Mumby, S.; Ruggeri, P.; Adcock, I. M.. - In: CURRENT OPINION IN PHARMACOLOGY. - ISSN 1471-4892. - 46:(2019), pp. 82-89. [10.1016/j.coph.2019.05.006]

Transcription inhibitors and inflammatory cell activity

Caramori G.;
2019-01-01

Abstract

Inflammation is a central feature of asthma and chronic obstructive pulmonary disease (COPD). Despite recent advances in the knowledge of the pathogenesis of asthma and COPD, much more research on the molecular mechanisms of asthma and COPD are needed to aid the logical development of new therapies for these common and important diseases, particularly in COPD where no new effective treatments currently exist. In the future the role of the activation/repression of different transcription factors and the genetic regulation of their expression in asthma and COPD may be an increasingly important aspect of research, as this may be one of the critical mechanisms regulating the expression of different clinical phenotypes and their responsiveness to therapy, particularly to anti-inflammatory drugs.
2019
Transcription inhibitors and inflammatory cell activity / Caramori, G.; Coppolino, I.; Cannavo, M. F.; Nucera, F.; Proietto, A.; Mumby, S.; Ruggeri, P.; Adcock, I. M.. - In: CURRENT OPINION IN PHARMACOLOGY. - ISSN 1471-4892. - 46:(2019), pp. 82-89. [10.1016/j.coph.2019.05.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2964117
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