The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support.The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.
Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance / Scaramuzzo, Gaetano; Nucera, Francesco; Asmundo, Alessio; Messina, Roberto; Mari, Matilde; Montanaro, Federica; Johansen, Matt D; Monaco, Francesco; Fadda, Guido; Tuccari, Giovanni; Hansbro, Nicole G; Hansbro, Philip M; Hansel, Trevor T; Adcock, Ian M; David, Antonio; Kirkham, Paul; Caramori, Gaetano; Volta, Carlo Alberto; Spadaro, Savino. - In: JOURNAL OF INFLAMMATION. - ISSN 1476-9255. - 20:1(2023), pp. 1-24. [10.1186/s12950-023-00333-2]
Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
Caramori, Gaetano;
2023-01-01
Abstract
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support.The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
