Background: The concept of early discharge ≤24 hours after Laparoscopic Cholecystectomy (LC) is still doubted in Italy. This prospective multicentre study aims to analyze the prevalence of patients undergoing elective LC who experienced a delayed discharge >24 hours in an extensive Italian national database and identify potential limiting factors of early discharge after LC. Methods: This is a prospective observational multicentre study performed from January 1, 2021 to December 31, 2021 by 90 Italian surgical units. Results: A total of 4664 patients were included in the study. Clinical reasons were found only for 850 patients (37.7%) discharged >24 hours after LC. After excluding patients with nonclinical reasons for delayed discharge >24 hours, 2 groups based on the length of hospitalization were created: the Early group (≤24 h; 2414 patients, 73.9%) and the Delayed group (>24 h; 850 patients, 26.1%). At the multivariate analysis, ASA III class ( P <0.0001), Charlson's Comorbidity Index (P=0.001), history of choledocholithiasis (P=0.03), presence of peritoneal adhesions (P<0.0001), operative time >60 min (P<0.0001), drain placement (P<0.0001), pain ( P =0.001), postoperative vomiting (P=0.001) and complications (P<0.0001) were independent predictors of delayed discharge >24 hours. Conclusions: The majority of delayed discharges >24 hours after LC in our study were unrelated to the surgery itself. ASA class >II, advanced comorbidity, the presence of peritoneal adhesions, prolonged operative time, and placement of abdominal drainage were intraoperative variables independently associated with failure of early discharge.
A prospective cohort analysis of the prevalence and predictive factors of delayed discharge after laparoscopic cholecystectomy in Italy: the DeDiLaCo Study / Cillara, Nicola; Podda, Mauro; Cicalò, Enrico; Sotgiu, Giovanni; Provenzano, Maria; Fransvea, Pietro; Poillucci, Gaetano; Sechi, Raffaele; Deserra, Antonello; D'Agostino, Francesca; Margiani, Carla; Scabini, Stefano; Pertile, Davide; De Rosa, Raffaele; Prosperi, Paolo; Bruscino, Alessandro; Di Bella, Annamaria; Casati, Massimiliano; Laface, Letizia; Abate, Emmanuele; Frontali, Alice; Michele Bonomi, Alessandro; Ferrario, Luca; Mucilli, Felice; Barone, Mirko; Borghi, Felice; Sasia, Diego; Giraudo, Giorgio; Puzziello, Alessandro; Loffredo, Andrea; Steccanella, Francesca; Donnarumma, Elio; Galleano, Raffaele; Malerba, Michele; Runfola, Matteo; Agus, Marcello; Fortunato, Federica; Giorgio Calò, Pietro; Medas, Fabio; Luigi Canu, Gian; Stella, Marco; Ferrara, Francesco; Baldi, Caterina; Benuzzi, Laura; Pisanu, Adolfo; Saba, Alessandra; Gessa, Emanuela; Muratore, Andrea; Calabrò, Marcello; Cuzzola, Bruno; Garino, Mauro; Marafante, Chiara; Farfaglia, Roberto; Pandolfo, Gianpiero; Pata, Giacomo; Lantone, Giulio; Marino, Fabio; Perrone, Fabrizio; Scognamillo, Fabrizio; Delogu, Daniele; Luigi Tilocca, Pier; Frena, Antonio; Malpaga, Anna; Bertelli, Giacomo; Memeo, Riccardo; Ferraro, Valentina; Libia, Annarita; Sarro, Giuliano; Marconi, Matteo; Nava, Samuele; Pierpaolo, Bordoni; Fleres, Francesco; Clarizia, Guglielmo; Alfieri, Sergio; Rosa, Fausto; Longo, Fabio; Restini, Enrico; Cianci, Pasquale; Capuzzolo, Sabino; Anania, Gabriele; Bombardini, Cristina; Urbani, Alessia; Bona, Davide; Aiolfi, Alberto; Lastraioli, Caterina; Di Paola, Massimiliano; Dall'Oglio, Anna; D'Eletto, Marco; Capelli, Patrizio; Conti, Luigi; Luzietti, Enrico; Banchini, Filippo; Manca, Giuseppe; Calo, Gabriele'; Centomze, Antonella; Andreano, Mauro; Sullo, Pasquale; Giuseppina, Oliva; Anastasi, Alessandro; Canonico, Giuseppe; Nelli, Tommaso; Trompetto, Mario; Gallo, Gaetano; Clerico, Giuseppe; Arganini, Marco; Palmeri, Matteo; Bonuso, Claudio; Mirabella, Antonello; V Marino, Marco; Vaccarella, Gianpaolo; Salzano, Francesco; Meccariello, Renato; Mastrorilli, Maurizio; Cesare Campanile, Fabio; Foti, Nicola; De Angelis, Monica; Domenico De Palma, Giovanni; Aprea, Giovanni; Palomba, Giuseppe; Milone, Marco; Capano, Mariana; Manigrasso, Michele; Baldazzi, Gianandrea; Cassini, Diletta; Gabriele Epifani, Angelo; Bottino, Vincenzo; Canfora, Alfonso; Ferronetti, Antonio; de Manzini, Nicolò; Biloslavo, Alan; Fracon, Stefano; Filauro, Marco; Barberis, Andrea; Azzinnaro, Antonio; Oliva, Alba; Razzore, Andrea; Di Maira, Lorenzo; Bima, Carlo; Gibin, Enrico; Peluso, Chiara; Perrotta, Nicola; Celiento, Marta; Scorzelli, Marco; Tuveri, Antonio; Madeddu, Francesco; Fois, Claudia; Russello, Domenico; Latteri, Saverio; Sofia, Maria; DEL RIO, Paolo; Cozzani, Federico; Giuffrida, Mario; Mariani, Pierpaolo; Giussani, Martina; Ansaloni, Luca; Maestri, Marcello; Tartaglia, Giuseppe; Caricato, Marco; Teresa Capolupo, Gabriella; Carannante, Filippo; Gambino, Giovanni; Bertino, Vanessa; Bonilauri, Stefano; Frazzetta, Giuseppe; Maria Amodio, Pietro; De Siena, Teresa; Zanzi, Federico; Guariniello, Anna; Rocco, Giuseppe; Mancini, Stefano; Sagnotta, Andrea; Solinas, Luigi; Porta, Andrea; Sambucci, Daniele; Monti, Eleonora; Quaglino, Francesco; Mantova, Serena; Fiore, Alessia; Costi, Renato; Virgilio, Edoardo; Montali, Filippo; Catarci, Marco; Apa, Daniela; Bertoldi, Innocenzo; Camandona, Michele; Bossotti, Maurizio; Palagi, Silvia; Doria, Emaunele; Caltagirone, Alice; Balani, Alessandro; Petronio, Barbara; Terranova, Susanna; Martuzzi, Federica; Romeo, Carlo; Carluccio, Raffaele; Neri, Silvia; Pio Auriemma, Pasquale; Prestigiacomo, Giorgia; Sala, Stefano; Colli, Francesco; Marini, Pierluigi; Di Cosimo, Carla; Gattolin, Andrea; Rimonda, Roberto; Travaglio, Elisabetta; Cotsoglou, Christian; Granieri, Stefano; Piero Chierici, Andrea; Tamini, Nicolò; Pitoni, Ludovica; Vico, Eleonora; Francesco Altomare, Donato; Martines, Gennaro; Tomasicchio, Giovanni; Coppola, Massimiliano; Aprile, Giovanna; Sau, Paolo; Del Papa, Mauro; Manzi, Fulvio; D'Amata, Gabriele; Cocorullo, Gianfranco; Venturelli, Paolina; Carollo, Giuseppe; Tondolo, Vincenzo; Dore, Andrea; Di Giorgio, Danilo; Pietro Paolo Gusai, Giovanni; Salaris, Claudia; Sanna, Silvia; Pignata, Giusto; Andreuccetti, Jacopo; D'Alessio, Rossella; Massani, Marco; Tutino, Roberta; Viola, Vincenzo; Persico Stella, Luigi; Diana, Massimo; Matteo Sampietro, Gianluca; Alessio Merlini, David; Sica, Giuseppe; Bagaglini, Giulia; Maria Manzia, Tommaso; Siracusa, Leandro; Tisone, Giuseppe; Ercolani, Giorgio; D'Acapito, Fabrizio; Di Pietrantonio, Daniela; Fiscon, Valentino; Portale, Giuseppe; Cipollari, Chiara; Sorrentino, Mario; Piccolo, Roberta; Cojutti, Alessandro; Canova, Gualtiero; Nicotera, Antonella; Zago, Marcello; De Montis, Giorgio; Castaldi, Fabio; Morena Morelli, Maria; Parma, Emilio; Paolini, Claudia; De Marco, Giovanni; Elter, Chiara; V Feo, Carlo; Fabbri, Nicolò; Severi, Silvia; Nasto, Aurelio; Patrone, Renato; Conti, Lorenzo; Rizzi, Andrea; Broggi, Luca; Danelli, Piergiorgio; Cammarata, Francesco; Fiore, Luigi; Grande, Michele; Campanelli, Michela; Grande, Simona. - In: SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES. - ISSN 1530-4515. - 33:5(2023), pp. 463-473. [10.1097/SLE.0000000000001207]
A prospective cohort analysis of the prevalence and predictive factors of delayed discharge after laparoscopic cholecystectomy in Italy: the DeDiLaCo Study
Paolo Del RioMembro del Collaboration Group
;Federico CozzaniMembro del Collaboration Group
;Mario GiuffridaMembro del Collaboration Group
;Alessia Fiore;Renato CostiMembro del Collaboration Group
;Edoardo VirgilioMembro del Collaboration Group
;Filippo MontaliMembro del Collaboration Group
;
2023-01-01
Abstract
Background: The concept of early discharge ≤24 hours after Laparoscopic Cholecystectomy (LC) is still doubted in Italy. This prospective multicentre study aims to analyze the prevalence of patients undergoing elective LC who experienced a delayed discharge >24 hours in an extensive Italian national database and identify potential limiting factors of early discharge after LC. Methods: This is a prospective observational multicentre study performed from January 1, 2021 to December 31, 2021 by 90 Italian surgical units. Results: A total of 4664 patients were included in the study. Clinical reasons were found only for 850 patients (37.7%) discharged >24 hours after LC. After excluding patients with nonclinical reasons for delayed discharge >24 hours, 2 groups based on the length of hospitalization were created: the Early group (≤24 h; 2414 patients, 73.9%) and the Delayed group (>24 h; 850 patients, 26.1%). At the multivariate analysis, ASA III class ( P <0.0001), Charlson's Comorbidity Index (P=0.001), history of choledocholithiasis (P=0.03), presence of peritoneal adhesions (P<0.0001), operative time >60 min (P<0.0001), drain placement (P<0.0001), pain ( P =0.001), postoperative vomiting (P=0.001) and complications (P<0.0001) were independent predictors of delayed discharge >24 hours. Conclusions: The majority of delayed discharges >24 hours after LC in our study were unrelated to the surgery itself. ASA class >II, advanced comorbidity, the presence of peritoneal adhesions, prolonged operative time, and placement of abdominal drainage were intraoperative variables independently associated with failure of early discharge.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
