The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been reported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and melanoma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of <3.4 (p < 0.001) and <831 (p < 0.001) were independent factors for OS in multivariate analysis. SII with LR, ROC, or CV significantly predicted OS in NSCLC (p = 0.002, p = 0.003, p = 0.003), RCC (p = 0.034, p = 0.014, p = 0.014), and melanoma (p = 0.038, p = 0.022, p = 0.019). NLR with LR and ROC cutoffs predicted OS in first line (p < 0.001 for both) and second line or beyond (p = 0.006 for both); likewise SII (p < 0.001; p = 0.002 and p < 0.001). NLR and SII are prognosticators in NSCLC, RCC, and melanoma treated with ICIs.
Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis / Anpalakhan, Shobana; Signori, Alessio; Cortellini, Alessio; Verzoni, Elena; Giusti, Raffaele; Aprile, Giuseppe; Ermacora, Paola; Catino, Annamaria; Pipitone, Stefania; Di Napoli, Marilena; Scotti, Vieri; Mazzoni, Francesca; Guglielmini, Pamela F.; Veccia, Antonello; Maruzzo, Marco; Schinzari, Giovanni; Casadei, Chiara; Grossi, Francesco; Rizzo, Mimma; Montesarchio, Vincenzo; Verderame, Francesco; Mencoboni, Manlio; Zustovich, Fable; Fratino, Lucia; Accettura, Caterina; Cinieri, Saverio; Tondini, Carlo Alberto; Camerini, Andrea; Banzi, Maria Chiara; Sorarù, Mariella; Zucali, Paolo Andrea; Vignani, Francesca; Ricciardi, Serena; Russo, Antonio; Cosenza, Agnese; Di Maio, Massimo; De Giorgi, Ugo; Pignata, Sandro; Giannarelli, Diana; Pinto, Carmine; Buti, Sebastiano; Fornarini, Giuseppe; Rebuzzi, Sara Elena; Rescigno, Pasquale; Addeo, Alfredo; Banna, Giuseppe L.; Bersanelli, Melissa. - In: ISCIENCE. - ISSN 2589-0042. - 26:11(2023), p. 107970. [10.1016/j.isci.2023.107970]
Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis
Buti, SebastianoConceptualization
;Bersanelli, Melissa
2023-01-01
Abstract
The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been reported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and melanoma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of <3.4 (p < 0.001) and <831 (p < 0.001) were independent factors for OS in multivariate analysis. SII with LR, ROC, or CV significantly predicted OS in NSCLC (p = 0.002, p = 0.003, p = 0.003), RCC (p = 0.034, p = 0.014, p = 0.014), and melanoma (p = 0.038, p = 0.022, p = 0.019). NLR with LR and ROC cutoffs predicted OS in first line (p < 0.001 for both) and second line or beyond (p = 0.006 for both); likewise SII (p < 0.001; p = 0.002 and p < 0.001). NLR and SII are prognosticators in NSCLC, RCC, and melanoma treated with ICIs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
