Three inorganic-organic hybrid diphosphates, templated by transition metal (2,6- (CH3)2C6H3NH3)2[MII(H2P2O7)2(H2O)2] (MII ¼Mn, Ni, Zn), were successfully synthesized by low speed of evaporation conditions after using the ion exchange chemical procedure. Their crystal structures were solved from single-crystal X-ray diffraction data. All compounds are isotypic and crystallize in the triclinic system with space group Pı. The crystal structure is built from the alternatively arranged inorganic [MII(H2P2O7)2(H2O)2]2- anions and organic [(CH3)2C6H3NH3]þ cations, stabilized by OeH/O and N eH/O hydrogen bonds and p$$$p stacking. The complexes were investigated by using such techniques: IR, TGA/DTA, UVevisible characterization techniques (Ni(II), Mn(II) compounds) and 1H, 13C, 31P NMR (Zn(II) compound). Hirshfeld surface analyses of the studied salts were also carried out. Finally, in vitro anticancer activities of compounds were further determined with reference to three human cancer cell lines (Human cervical (A431), pancreatic (PSN1) and human ovarian cell lines (2008)). Hybrid complexes, based on manganese, nickel and zinc, displayed in vitro efficient antitumor activity compared with the positive reference drug cisplatin.

Hybrid MII-organic-diphosphate hydrates (MII = Mn, Ni and Zn): Structural characterization, hirshfeld surface analysis and antitumoral activity / Moghdad, I.; Mbarek, A.; Costantino, F.; Nazzareni, S.; Naili, H.. - In: JOURNAL OF MOLECULAR STRUCTURE. - ISSN 0022-2860. - 1202:(2020), p. 127326. [10.1016/j.molstruc.2019.127326]

Hybrid MII-organic-diphosphate hydrates (MII = Mn, Ni and Zn): Structural characterization, hirshfeld surface analysis and antitumoral activity

Nazzareni S.;
2020-01-01

Abstract

Three inorganic-organic hybrid diphosphates, templated by transition metal (2,6- (CH3)2C6H3NH3)2[MII(H2P2O7)2(H2O)2] (MII ¼Mn, Ni, Zn), were successfully synthesized by low speed of evaporation conditions after using the ion exchange chemical procedure. Their crystal structures were solved from single-crystal X-ray diffraction data. All compounds are isotypic and crystallize in the triclinic system with space group Pı. The crystal structure is built from the alternatively arranged inorganic [MII(H2P2O7)2(H2O)2]2- anions and organic [(CH3)2C6H3NH3]þ cations, stabilized by OeH/O and N eH/O hydrogen bonds and p$$$p stacking. The complexes were investigated by using such techniques: IR, TGA/DTA, UVevisible characterization techniques (Ni(II), Mn(II) compounds) and 1H, 13C, 31P NMR (Zn(II) compound). Hirshfeld surface analyses of the studied salts were also carried out. Finally, in vitro anticancer activities of compounds were further determined with reference to three human cancer cell lines (Human cervical (A431), pancreatic (PSN1) and human ovarian cell lines (2008)). Hybrid complexes, based on manganese, nickel and zinc, displayed in vitro efficient antitumor activity compared with the positive reference drug cisplatin.
2020
Hybrid MII-organic-diphosphate hydrates (MII = Mn, Ni and Zn): Structural characterization, hirshfeld surface analysis and antitumoral activity / Moghdad, I.; Mbarek, A.; Costantino, F.; Nazzareni, S.; Naili, H.. - In: JOURNAL OF MOLECULAR STRUCTURE. - ISSN 0022-2860. - 1202:(2020), p. 127326. [10.1016/j.molstruc.2019.127326]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2961216
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 8
social impact