: Nowadays, treatment of metastatic breast cancer (MBC) has been enriched with novel therapeutical strategies. Metronomic chemotherapy (mCHT) is a continuous and frequent administration of chemotherapy at a lower dose and so whit less toxicity. Thus, this strategy could be attractive for elderly MBC patients. Aim of this analysis is to provide insights into mCHT's activity in a real-life setting of elderly MBC patients. Data of patients ≥ 75 years old included in VICTOR-6 study were analyzed. VICTOR-6 is a multicentre, Italian, retrospective study, which collected data on mCHT in MBC patients treated between 2011 and 2016. A total of 112 patients were included. At the beginning of mCHT, median age was 81 years (75-98) and in 33% of the patients mCHT was the first line choice. Overall Response Rate (ORR) and Disease Control Rate (DCR) were 27.9% and 79.3%, respectively. Median PFS ranged between 7.6 and 9.1 months, OS between 14.1 and 18.5 months. The most relevant toxicity was the hematological one (24.1%); severe toxicity (grade 3-4) ranged from 0.9% for skin toxicity up to 8% for hematologic one. This is a large study about mCHT in elderly MBC patients, providing insights to be further investigated in this subgroup of frail patients.

Final results of the real-life observational VICTOR-6 study on metronomic chemotherapy in elderly metastatic breast cancer (MBC) patients / Trevisan, B; Pepe, F F; Vallini, I; Montagna, E; Amoroso, D; Berardi, R; Butera, A; Cagossi, K; Cavanna, L; Ciccarese, M; Cinieri, S; Cretella, E; De Conciliis, E; Febbraro, A; Ferraù, F; Ferzi, A; Baldelli, A; Fontana, A; Gambaro, A R; Garrone, O; Gebbia, V; Generali, D; Gianni, L; Giovanardi, F; Grassadonia, A; Leonardi, V; Sarti, S; Musolino, A; Nicolini, M; Putzu, C; Riccardi, F; Santini, D; Sarobba, M G; Schintu, M G; Scognamiglio, G; Spadaro, P; Taverniti, C; Toniolo, D; Tralongo, P; Turletti, A; Valenza, R; Valerio, M R; Vici, P; Clivio, L; Torri, V; Cazzaniga, M E. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 13:1(2023), p. 12255. [10.1038/s41598-023-39386-x]

Final results of the real-life observational VICTOR-6 study on metronomic chemotherapy in elderly metastatic breast cancer (MBC) patients

Musolino, A;
2023-01-01

Abstract

: Nowadays, treatment of metastatic breast cancer (MBC) has been enriched with novel therapeutical strategies. Metronomic chemotherapy (mCHT) is a continuous and frequent administration of chemotherapy at a lower dose and so whit less toxicity. Thus, this strategy could be attractive for elderly MBC patients. Aim of this analysis is to provide insights into mCHT's activity in a real-life setting of elderly MBC patients. Data of patients ≥ 75 years old included in VICTOR-6 study were analyzed. VICTOR-6 is a multicentre, Italian, retrospective study, which collected data on mCHT in MBC patients treated between 2011 and 2016. A total of 112 patients were included. At the beginning of mCHT, median age was 81 years (75-98) and in 33% of the patients mCHT was the first line choice. Overall Response Rate (ORR) and Disease Control Rate (DCR) were 27.9% and 79.3%, respectively. Median PFS ranged between 7.6 and 9.1 months, OS between 14.1 and 18.5 months. The most relevant toxicity was the hematological one (24.1%); severe toxicity (grade 3-4) ranged from 0.9% for skin toxicity up to 8% for hematologic one. This is a large study about mCHT in elderly MBC patients, providing insights to be further investigated in this subgroup of frail patients.
2023
Final results of the real-life observational VICTOR-6 study on metronomic chemotherapy in elderly metastatic breast cancer (MBC) patients / Trevisan, B; Pepe, F F; Vallini, I; Montagna, E; Amoroso, D; Berardi, R; Butera, A; Cagossi, K; Cavanna, L; Ciccarese, M; Cinieri, S; Cretella, E; De Conciliis, E; Febbraro, A; Ferraù, F; Ferzi, A; Baldelli, A; Fontana, A; Gambaro, A R; Garrone, O; Gebbia, V; Generali, D; Gianni, L; Giovanardi, F; Grassadonia, A; Leonardi, V; Sarti, S; Musolino, A; Nicolini, M; Putzu, C; Riccardi, F; Santini, D; Sarobba, M G; Schintu, M G; Scognamiglio, G; Spadaro, P; Taverniti, C; Toniolo, D; Tralongo, P; Turletti, A; Valenza, R; Valerio, M R; Vici, P; Clivio, L; Torri, V; Cazzaniga, M E. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 13:1(2023), p. 12255. [10.1038/s41598-023-39386-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2956073
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