Four human cytomegalovirus strains with double resistance to both ganciclovir and foscarnet were recovered from acquired immunodeficiency syndrome (AIDS) patients. The four isolates were genetically unrelated and each of them consisted of a single viral population. In addition, for each isolate, UL97 and UL54 open reading frames sequencing showed a single aminoacid change in a conserved domain of each of the two genes.

Four dually resistant human cytomegalovirus strains from AIDS patients: Single mutations in UL97 and UL54 open reading frames are responsible for ganciclovir- and foscarnet-specific resistance, respectively / Baldanti, F.; Sarasini, A.; Silini, E.; Barbi, M.; Lazzarin, A.; Biron, K. K.; Gerna, G.. - In: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. SUPPLEMENTUM. - ISSN 0300-8878. - 99(1996), pp. 103-104.

Four dually resistant human cytomegalovirus strains from AIDS patients: Single mutations in UL97 and UL54 open reading frames are responsible for ganciclovir- and foscarnet-specific resistance, respectively

Silini E.;
1996-01-01

Abstract

Four human cytomegalovirus strains with double resistance to both ganciclovir and foscarnet were recovered from acquired immunodeficiency syndrome (AIDS) patients. The four isolates were genetically unrelated and each of them consisted of a single viral population. In addition, for each isolate, UL97 and UL54 open reading frames sequencing showed a single aminoacid change in a conserved domain of each of the two genes.
1996
Four dually resistant human cytomegalovirus strains from AIDS patients: Single mutations in UL97 and UL54 open reading frames are responsible for ganciclovir- and foscarnet-specific resistance, respectively / Baldanti, F.; Sarasini, A.; Silini, E.; Barbi, M.; Lazzarin, A.; Biron, K. K.; Gerna, G.. - In: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. SUPPLEMENTUM. - ISSN 0300-8878. - 99(1996), pp. 103-104.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2953056
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 35
  • ???jsp.display-item.citation.isi??? ND
social impact