Endothelial cell dysfunction is a term which implies the dysregulation of normal endothelial cell functions, including impairment of the barrier functions, control of vascular tone, disturbance of proliferative, migratory and morphogenic capacities of endothelial cells, as well as control of leukocyte trafficking. MicroRNAs are short non-coding RNAs that have emerged as critical regulators of gene expression acting predominantly at the post-transcriptional level. This review summarizes the latest insights in the identification of endothelial-specific microRNAs and their targets, as well as their roles in controlling endothelial cell functions in both autocrine and paracrine manner. In addition, we discuss the therapeutic potential for the treatment of endothelial cell dysfunction and associated vascular pathophysiological conditions. (c) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

MicroRNAs as pharmacological targets in endothelial cell function and dysfunction / Chamorro-Jorganes, A; Araldi, E; Suarez, Y. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 75:(2013), pp. 15-27. [10.1016/j.phrs.2013.04.002]

MicroRNAs as pharmacological targets in endothelial cell function and dysfunction

Araldi E;
2013-01-01

Abstract

Endothelial cell dysfunction is a term which implies the dysregulation of normal endothelial cell functions, including impairment of the barrier functions, control of vascular tone, disturbance of proliferative, migratory and morphogenic capacities of endothelial cells, as well as control of leukocyte trafficking. MicroRNAs are short non-coding RNAs that have emerged as critical regulators of gene expression acting predominantly at the post-transcriptional level. This review summarizes the latest insights in the identification of endothelial-specific microRNAs and their targets, as well as their roles in controlling endothelial cell functions in both autocrine and paracrine manner. In addition, we discuss the therapeutic potential for the treatment of endothelial cell dysfunction and associated vascular pathophysiological conditions. (c) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
2013
MicroRNAs as pharmacological targets in endothelial cell function and dysfunction / Chamorro-Jorganes, A; Araldi, E; Suarez, Y. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 75:(2013), pp. 15-27. [10.1016/j.phrs.2013.04.002]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2951981
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 91
  • ???jsp.display-item.citation.isi??? 86
social impact