Administration of multiple, sublethal doses of organophosphorus insecticides induces the development of tolerance to their toxicity. Among the differebt hypotheses investigated to explain the mechanism of this phenomenon, the one which has received the greatest experimental support is a downregulation of the muscarinic cholinergic receptors. Subsensitivity to cholinergic agonist has been demonstrated in vivo and in vitro in isolated organ preparations. Receptor bindng experiments using muscarinicantagonists and agonists revealed a decrease of cholinergic receptors in central and peripheral tissues. Tolerance to another class of acetylcholinesterase inhibitors, carbamates has also been demonstrated. Difference from and similarities to organophosphate tolerance are discussed. © 1982.
Tolerance to anticholinesterase compounds in mammals / Costa, L. G.; Schwab, B. W.; Murphy, S. D.. - In: TOXICOLOGY. - ISSN 0300-483X. - 25:2-3(1982), pp. 79-97. [10.1016/0300-483X(82)90021-X]
Tolerance to anticholinesterase compounds in mammals
Costa L. G.;
1982-01-01
Abstract
Administration of multiple, sublethal doses of organophosphorus insecticides induces the development of tolerance to their toxicity. Among the differebt hypotheses investigated to explain the mechanism of this phenomenon, the one which has received the greatest experimental support is a downregulation of the muscarinic cholinergic receptors. Subsensitivity to cholinergic agonist has been demonstrated in vivo and in vitro in isolated organ preparations. Receptor bindng experiments using muscarinicantagonists and agonists revealed a decrease of cholinergic receptors in central and peripheral tissues. Tolerance to another class of acetylcholinesterase inhibitors, carbamates has also been demonstrated. Difference from and similarities to organophosphate tolerance are discussed. © 1982.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
