We describe the first gold(i)-catalysed intramolecular hydroarylation of alkynes for the straightforward synthesis of inherently chiral calix[4]arenes. This step- and atom-economical approach, which exploits a formal meta-functionalisation of the calix[4]arene macrocycle, is able to deliver an ample family of N-heterocyclic, chiral compounds in high yields and functional group tolerance.

Gold(I)-catalysed hydroarylations of alkynes for the synthesis of inherently chiral calix[4]arenes / Giovanardi, Gabriele; Scarica, Gabriele; Pirovano, Valentina; Secchi, Andrea; Cera, Gianpiero. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 21:19(2023), pp. 4072-4083. [10.1039/d3ob00603d]

Gold(I)-catalysed hydroarylations of alkynes for the synthesis of inherently chiral calix[4]arenes

Giovanardi, Gabriele;Scarica, Gabriele;Secchi, Andrea
;
Cera, Gianpiero
2023-01-01

Abstract

We describe the first gold(i)-catalysed intramolecular hydroarylation of alkynes for the straightforward synthesis of inherently chiral calix[4]arenes. This step- and atom-economical approach, which exploits a formal meta-functionalisation of the calix[4]arene macrocycle, is able to deliver an ample family of N-heterocyclic, chiral compounds in high yields and functional group tolerance.
2023
Gold(I)-catalysed hydroarylations of alkynes for the synthesis of inherently chiral calix[4]arenes / Giovanardi, Gabriele; Scarica, Gabriele; Pirovano, Valentina; Secchi, Andrea; Cera, Gianpiero. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 21:19(2023), pp. 4072-4083. [10.1039/d3ob00603d]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2945731
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