We describe the first gold(i)-catalysed intramolecular hydroarylation of alkynes for the straightforward synthesis of inherently chiral calix[4]arenes. This step- and atom-economical approach, which exploits a formal meta-functionalisation of the calix[4]arene macrocycle, is able to deliver an ample family of N-heterocyclic, chiral compounds in high yields and functional group tolerance.
Gold(I)-catalysed hydroarylations of alkynes for the synthesis of inherently chiral calix[4]arenes / Giovanardi, Gabriele; Scarica, Gabriele; Pirovano, Valentina; Secchi, Andrea; Cera, Gianpiero. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 21:19(2023), pp. 4072-4083. [10.1039/d3ob00603d]
Gold(I)-catalysed hydroarylations of alkynes for the synthesis of inherently chiral calix[4]arenes
Giovanardi, Gabriele;Scarica, Gabriele;Secchi, Andrea
;Cera, Gianpiero
2023-01-01
Abstract
We describe the first gold(i)-catalysed intramolecular hydroarylation of alkynes for the straightforward synthesis of inherently chiral calix[4]arenes. This step- and atom-economical approach, which exploits a formal meta-functionalisation of the calix[4]arene macrocycle, is able to deliver an ample family of N-heterocyclic, chiral compounds in high yields and functional group tolerance.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
