: Oxygen supplementation is widely used in neonatal care, however, it can also cause toxic effects if not used properly. Therefore, it appears crucial to find a balance in oxygen administration to avoid damage as a consequence of its insufficient or excessive use. Oxygen toxicity is mainly due to the production of oxygen radicals, molecules normally produced in humans and involved in a myriad of physiological reactions. In the neonatal period, an imbalance between oxidants and antioxidant defenses, the so-called oxidative stress, might occur, causing severe pathological consequences. In this review, we focus on the mechanisms of the production of oxygen radicals and their physiological functions in determining a set of diseases grouped together as "free radical diseases in the neonate". In addition, we describe the evolution of the oxygenation target recommendations during neonatal resuscitation and post-stabilization phases with the aim to define the best oxygen administration according to the newest evidence.
Oxygen for the Newborn: Friend or Foe? / Perrone, Serafina; Manti, Sara; Petrolini, Chiara; Dell'Orto, Valentina Giovanna; Boscarino, Giovanni; Ceccotti, Chiara; Bertini, Mattia; Buonocore, Giuseppe; Esposito, Susanna Maria Roberta; Gitto, Eloisa. - In: CHILDREN. - ISSN 2227-9067. - 10:3(2023), p. 579. [10.3390/children10030579]
Oxygen for the Newborn: Friend or Foe?
Perrone, Serafina;Petrolini, Chiara;Dell'Orto, Valentina Giovanna;Boscarino, Giovanni;Esposito, Susanna Maria Roberta;
2023-01-01
Abstract
: Oxygen supplementation is widely used in neonatal care, however, it can also cause toxic effects if not used properly. Therefore, it appears crucial to find a balance in oxygen administration to avoid damage as a consequence of its insufficient or excessive use. Oxygen toxicity is mainly due to the production of oxygen radicals, molecules normally produced in humans and involved in a myriad of physiological reactions. In the neonatal period, an imbalance between oxidants and antioxidant defenses, the so-called oxidative stress, might occur, causing severe pathological consequences. In this review, we focus on the mechanisms of the production of oxygen radicals and their physiological functions in determining a set of diseases grouped together as "free radical diseases in the neonate". In addition, we describe the evolution of the oxygenation target recommendations during neonatal resuscitation and post-stabilization phases with the aim to define the best oxygen administration according to the newest evidence.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.