Objective: To investigate the impact of fetal growth restriction (FGR) on hormonal regulation of post-natal growth and glucose metabolism [via insulin and growth hormone (GH)/Insulin-like Growth factor 1 (IGF1) axis pathways] in small for gestational age (SGA) neonates. Methods: We conducted a monocentric observational prospective comparative study on 73 singleton babies born with a weight inferior to 2,000 g. We analyzed auxological (weight, height and head circumference), and hormonal (GH, IGF1, and insulin plasma concentrations) data comparing SGA and appropriate for gestational age (AGA) neonates, between day 1 and 60. Results: One third (23/73) of the neonates were SGA. Twenty-five percent (18/73) required insulin for idiopathic hyperglycemia of prematurity and were smaller in weight and head circumference at discharge. In the SGA group compared with the AGA group, GH plasma concentrations were higher at day 3 (70.1 vs. 38.0 mIU/L) and IGF1 plasma concentrations were higher at day 10 (29.0 vs. 18.7 ng/ml). Conclusions: SGA neonates displayed resistance to GH and IGF1, concomitant to insulin resistance. This could partially explain the initial defective catch-up growth and, later in life, the higher prevalence of metabolic syndrome in this population.

Small for Gestational Age Preterm Neonates Exhibit Defective GH/IGF1 Signaling Pathway / Motte-Signoret, E.; Shankar-Aguilera, S.; Brailly-Tabard, S.; Soreze, Y.; Dell Orto, V.; Ben Ammar, R.; De Luca, D.; Boileau, P.. - In: FRONTIERS IN PEDIATRICS. - ISSN 2296-2360. - 9:(2021), p. 711400.711400. [10.3389/fped.2021.711400]

Small for Gestational Age Preterm Neonates Exhibit Defective GH/IGF1 Signaling Pathway

Dell Orto V.;
2021-01-01

Abstract

Objective: To investigate the impact of fetal growth restriction (FGR) on hormonal regulation of post-natal growth and glucose metabolism [via insulin and growth hormone (GH)/Insulin-like Growth factor 1 (IGF1) axis pathways] in small for gestational age (SGA) neonates. Methods: We conducted a monocentric observational prospective comparative study on 73 singleton babies born with a weight inferior to 2,000 g. We analyzed auxological (weight, height and head circumference), and hormonal (GH, IGF1, and insulin plasma concentrations) data comparing SGA and appropriate for gestational age (AGA) neonates, between day 1 and 60. Results: One third (23/73) of the neonates were SGA. Twenty-five percent (18/73) required insulin for idiopathic hyperglycemia of prematurity and were smaller in weight and head circumference at discharge. In the SGA group compared with the AGA group, GH plasma concentrations were higher at day 3 (70.1 vs. 38.0 mIU/L) and IGF1 plasma concentrations were higher at day 10 (29.0 vs. 18.7 ng/ml). Conclusions: SGA neonates displayed resistance to GH and IGF1, concomitant to insulin resistance. This could partially explain the initial defective catch-up growth and, later in life, the higher prevalence of metabolic syndrome in this population.
2021
Small for Gestational Age Preterm Neonates Exhibit Defective GH/IGF1 Signaling Pathway / Motte-Signoret, E.; Shankar-Aguilera, S.; Brailly-Tabard, S.; Soreze, Y.; Dell Orto, V.; Ben Ammar, R.; De Luca, D.; Boileau, P.. - In: FRONTIERS IN PEDIATRICS. - ISSN 2296-2360. - 9:(2021), p. 711400.711400. [10.3389/fped.2021.711400]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2939844
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