Multiple myeloma (MM) is a monoclonal gammopathy characterized by biological heterogeneity and unregulated proliferation of plasma cells (PCs) in bone marrow (BM). MM is a multistep process based on genomic instability, epigenetic dysregulation and a tight cross-talk with the BM microenvironment that plays a pivotal role supporting the proliferation, survival, drug-resistance and homing of PCs. The BM microenvironment consists of a hematopoietic and a non-hematopoietic compartment, which cooperate to create a tumor environment. Among the non-hematopoietic component, mesenchymal stromal cells (MSCs) and osteoblasts (OBs) appear transcriptionally and functionally different in MM patients compared to healthy donors (HDs) and to patients with pre-malignant monoclonal gammopathies. Alterations of both MSCs and OBs underly the osteolytic lesions that characterize myeloma-associated bone disease. In this review, we will discuss the different characteristics of MSCs and OBs in MM patients, analyzing the transcriptome, the deregulated molecular pathways and the role performed by miRNAs and exosome in the pathophysiology of MM.

Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma / Iannozzi, Nicolas Thomas; Marchica, Valentina; Toscani, Denise; Burroughs Garcìa, Jessica; Giuliani, Nicola; Storti, Paola. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 23:24(2022), p. 15448. [10.3390/ijms232415448]

Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma

Iannozzi, Nicolas Thomas;Marchica, Valentina;Toscani, Denise;Giuliani, Nicola
;
Storti, Paola
2022-01-01

Abstract

Multiple myeloma (MM) is a monoclonal gammopathy characterized by biological heterogeneity and unregulated proliferation of plasma cells (PCs) in bone marrow (BM). MM is a multistep process based on genomic instability, epigenetic dysregulation and a tight cross-talk with the BM microenvironment that plays a pivotal role supporting the proliferation, survival, drug-resistance and homing of PCs. The BM microenvironment consists of a hematopoietic and a non-hematopoietic compartment, which cooperate to create a tumor environment. Among the non-hematopoietic component, mesenchymal stromal cells (MSCs) and osteoblasts (OBs) appear transcriptionally and functionally different in MM patients compared to healthy donors (HDs) and to patients with pre-malignant monoclonal gammopathies. Alterations of both MSCs and OBs underly the osteolytic lesions that characterize myeloma-associated bone disease. In this review, we will discuss the different characteristics of MSCs and OBs in MM patients, analyzing the transcriptome, the deregulated molecular pathways and the role performed by miRNAs and exosome in the pathophysiology of MM.
2022
Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma / Iannozzi, Nicolas Thomas; Marchica, Valentina; Toscani, Denise; Burroughs Garcìa, Jessica; Giuliani, Nicola; Storti, Paola. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 23:24(2022), p. 15448. [10.3390/ijms232415448]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2937933
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