Malaria infection does not generate protective immunity, even though it induces a strong humoral and cellular immune response. The parasite evades host defense by its high degree of antigenic variability and inducing immunosuppressive mechanisms. A protective vaccine for malaria is under investigation, the most recent experiences however have pointed out the need of a multicomponent vaccine stimulating both the humoral and cellular immune response in order to obtain a protective response. Even if preliminary, the first successful trial has been conducted with a multicomponent synthetic vaccine, which showed protection to P. falciparum in 38,8% of the cases.
Malaria immunity mechanisms / Missale, G.; Menozzi, G.; Bertoni, R.; Pasetti, G. C.; Fiaccadori, F.. - In: GIORNALE DI MALATTIE INFETTIVE E PARASSITARIE. - ISSN 0017-0321. - 46:(1994), pp. 744-747.
Malaria immunity mechanisms
Missale G.;Fiaccadori F.
1994-01-01
Abstract
Malaria infection does not generate protective immunity, even though it induces a strong humoral and cellular immune response. The parasite evades host defense by its high degree of antigenic variability and inducing immunosuppressive mechanisms. A protective vaccine for malaria is under investigation, the most recent experiences however have pointed out the need of a multicomponent vaccine stimulating both the humoral and cellular immune response in order to obtain a protective response. Even if preliminary, the first successful trial has been conducted with a multicomponent synthetic vaccine, which showed protection to P. falciparum in 38,8% of the cases.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
