Fluoride controlled release systems in the prevention of dental caries

Research on drug controlled release devices indicate, in particular with regards to fluoride, the utility of such formulations in dental caries prevention. With this technique, a steady and constant topical action in the mouth is achieved. The new system, called IFRD and applied on the vestibular surface of the first upper molars, is able to release and to increase the daily fluoride concentration in the saliva during 6 months with no adverse effects or intolerance by patients.