First-line therapies based on immune-checkpoint inhibitors (ICIs) significantly improved survival of metastatic renal cell carcinoma (mRCC) patients. Cabozantinib was shown to target kinases involved in immune-escape and to prolong survival in patients pre-treated with tyrosine-kinase-inhibitors (TKIs). The impact of ICIs combinations in first line on subsequent therapies is still unclear.

A multicenter phase 2 single arm study of cabozantinib in patients with advanced or unresectable renal cell carcinoma pre-treated with one immune-checkpoint inhibitor: The BREAKPOINT trial (Meet-Uro trial 03) / Procopio, Giuseppe; Claps, Mélanie; Pircher, Chiara; Porcu, Luca; Sepe, Pierangela; Guadalupi, Valentina; De Giorgi, Ugo; Bimbatti, Davide; Nolè, Franco; Carrozza, Francesco; Buti, Sebastiano; Iacovelli, Roberto; Ciccarese, Chiara; Masini, Cristina; Baldessari, Cinzia; Doni, Laura; Cusmai, Antonio; Gernone, Angela; Scagliarini, Sarah; Pignata, Sandro; de Braud, Filippo; Verzoni, Elena. - In: TUMORI. - ISSN 0300-8916. - (2022), p. 3008916221138881. [10.1177/03008916221138881]

A multicenter phase 2 single arm study of cabozantinib in patients with advanced or unresectable renal cell carcinoma pre-treated with one immune-checkpoint inhibitor: The BREAKPOINT trial (Meet-Uro trial 03)

Buti, Sebastiano;
2022-01-01

Abstract

First-line therapies based on immune-checkpoint inhibitors (ICIs) significantly improved survival of metastatic renal cell carcinoma (mRCC) patients. Cabozantinib was shown to target kinases involved in immune-escape and to prolong survival in patients pre-treated with tyrosine-kinase-inhibitors (TKIs). The impact of ICIs combinations in first line on subsequent therapies is still unclear.
2022
A multicenter phase 2 single arm study of cabozantinib in patients with advanced or unresectable renal cell carcinoma pre-treated with one immune-checkpoint inhibitor: The BREAKPOINT trial (Meet-Uro trial 03) / Procopio, Giuseppe; Claps, Mélanie; Pircher, Chiara; Porcu, Luca; Sepe, Pierangela; Guadalupi, Valentina; De Giorgi, Ugo; Bimbatti, Davide; Nolè, Franco; Carrozza, Francesco; Buti, Sebastiano; Iacovelli, Roberto; Ciccarese, Chiara; Masini, Cristina; Baldessari, Cinzia; Doni, Laura; Cusmai, Antonio; Gernone, Angela; Scagliarini, Sarah; Pignata, Sandro; de Braud, Filippo; Verzoni, Elena. - In: TUMORI. - ISSN 0300-8916. - (2022), p. 3008916221138881. [10.1177/03008916221138881]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2934891
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