Historically, vitamin D is recognized as an essential component for the maintenance of the musculoskeletal system. The immunomodulatory role of vitamin D in health and disease has gained much interest in recent years due to the many pathologies that share underlying immunological features where vitamin D has been shown to exert a potential role. Evidence from pre-clinical studies show that vitamin D elicits biological effects on both the innate and adaptive immune systems. Furthermore, in vivo studies have shown that administration of vitamin D can lead to changes in or the development of a range of immune-related diseases. This encourages the hypothesis that data derived from clinical and epidemiological studies connect vitamin D with the incidence and severity of many immune-mediated disorders such as rheumatoid arthritis, diabetes, and infectious diseases. Since some other immune-mediated diseases share similar features to that of viral infection such as COVID-19, in this review, we examined these other areas and the role of vitamin D in these diseases.

The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion / Giannini, Sandro; Rossini, Maurizio; Giusti, Andrea; Minisola, Salvatore; Napoli, Nicola; Passeri, Giovanni; Luigi Sinigaglia, And. - In: NUTRIENTS. - ISSN 2072-6643. - 14:14(2022), pp. 1-21. [10.3390/nu14030473]

The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion

Salvatore Minisola;Giovanni Passeri;
2022-01-01

Abstract

Historically, vitamin D is recognized as an essential component for the maintenance of the musculoskeletal system. The immunomodulatory role of vitamin D in health and disease has gained much interest in recent years due to the many pathologies that share underlying immunological features where vitamin D has been shown to exert a potential role. Evidence from pre-clinical studies show that vitamin D elicits biological effects on both the innate and adaptive immune systems. Furthermore, in vivo studies have shown that administration of vitamin D can lead to changes in or the development of a range of immune-related diseases. This encourages the hypothesis that data derived from clinical and epidemiological studies connect vitamin D with the incidence and severity of many immune-mediated disorders such as rheumatoid arthritis, diabetes, and infectious diseases. Since some other immune-mediated diseases share similar features to that of viral infection such as COVID-19, in this review, we examined these other areas and the role of vitamin D in these diseases.
2022
The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion / Giannini, Sandro; Rossini, Maurizio; Giusti, Andrea; Minisola, Salvatore; Napoli, Nicola; Passeri, Giovanni; Luigi Sinigaglia, And. - In: NUTRIENTS. - ISSN 2072-6643. - 14:14(2022), pp. 1-21. [10.3390/nu14030473]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2934132
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