Despite increasing use of next-generation sequencing (NGS), data concerning the gain in germline pathogenic variants (PVs) remain scanty, especially with respect to uncanonical ones. We aimed to verify the impact of different cancer predisposition genes (CPGs) on colorectal cancer (CRC) in patients referred for genetic evaluation.

Canonical and uncanonical pathogenic germline variants in colorectal cancer patients by next-generation sequencing in a European referral center / Poliani, L; Greco, L; Barile, M; Buono, A Dal; Bianchi, P; Basso, G; Giatti, V; Genuardi, M; Malesci, A; Laghi, L. - In: ESMO OPEN. - ISSN 2059-7029. - 7:6(2022), p. 100607. [10.1016/j.esmoop.2022.100607]

Canonical and uncanonical pathogenic germline variants in colorectal cancer patients by next-generation sequencing in a European referral center

Barile, M;Genuardi, M;Laghi, L
2022-01-01

Abstract

Despite increasing use of next-generation sequencing (NGS), data concerning the gain in germline pathogenic variants (PVs) remain scanty, especially with respect to uncanonical ones. We aimed to verify the impact of different cancer predisposition genes (CPGs) on colorectal cancer (CRC) in patients referred for genetic evaluation.
Canonical and uncanonical pathogenic germline variants in colorectal cancer patients by next-generation sequencing in a European referral center / Poliani, L; Greco, L; Barile, M; Buono, A Dal; Bianchi, P; Basso, G; Giatti, V; Genuardi, M; Malesci, A; Laghi, L. - In: ESMO OPEN. - ISSN 2059-7029. - 7:6(2022), p. 100607. [10.1016/j.esmoop.2022.100607]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2933777
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