Targeting Kirsten Rat Sarcoma (KRAS) has been deemed impossible for long time, but new drugs have recently demonstrated promising results. Evidence on the outcome of KRAS-mutant advanced-NSCLC treated with new standard regimens are still scarce. Thus, we aimed at assessing the incidence and clinical impact of KRAS mutations in a real-life population of advanced-NSCLC, exploring the prognostic significance of distinct alterations.

Therapeutic Outcomes and Clinical Features of Advanced Non-Small Cell Lung Cancer Carrying KRAS Mutations: A Multicenter Real-life Retrospective Study / Mazzaschi, G., Perrone, F., Minari, R., Verzè, M., Azzoni, C., Bottarelli, L., Pluchino, M., Armillotta, M.P., Ubaldi, A., Altimari, A., Gruppioni, E., Sperandi, F., Andrini, E., Guaitoli, G., Bettelli, S., Longo, L., Bertolini, F., Barbieri, F., Pagano, M., Bonelli, C., et al.. - In: CLINICAL LUNG CANCER. - ISSN 1525-7304. - 23:7(2022), pp. e478-e488. [10.1016/j.cllc.2022.07.005]

Therapeutic Outcomes and Clinical Features of Advanced Non-Small Cell Lung Cancer Carrying KRAS Mutations: A Multicenter Real-life Retrospective Study

Mazzaschi, Giulia;Minari, Roberta;Azzoni, Cinzia;Ubaldi, Annalisa;Gnetti, Letizia;Tiseo, Marcello
2022-01-01

Abstract

Targeting Kirsten Rat Sarcoma (KRAS) has been deemed impossible for long time, but new drugs have recently demonstrated promising results. Evidence on the outcome of KRAS-mutant advanced-NSCLC treated with new standard regimens are still scarce. Thus, we aimed at assessing the incidence and clinical impact of KRAS mutations in a real-life population of advanced-NSCLC, exploring the prognostic significance of distinct alterations.
2022
Therapeutic Outcomes and Clinical Features of Advanced Non-Small Cell Lung Cancer Carrying KRAS Mutations: A Multicenter Real-life Retrospective Study / Mazzaschi, G., Perrone, F., Minari, R., Verzè, M., Azzoni, C., Bottarelli, L., Pluchino, M., Armillotta, M.P., Ubaldi, A., Altimari, A., Gruppioni, E., Sperandi, F., Andrini, E., Guaitoli, G., Bettelli, S., Longo, L., Bertolini, F., Barbieri, F., Pagano, M., Bonelli, C., et al.. - In: CLINICAL LUNG CANCER. - ISSN 1525-7304. - 23:7(2022), pp. e478-e488. [10.1016/j.cllc.2022.07.005]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2933360
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