Background: How the relationship between obesity and MRI-defined neural properties varies across distinct stages of cognitive impairment due to Alzheimer's disease is unclear. Objective: We used multimodal neuroimaging to clarify this relationship. Methods: Scans were acquired from 47 patients clinically diagnosed with mild Alzheimer's disease dementia, 68 patients with mild cognitive impairment, and 57 cognitively healthy individuals. Voxel-wise associations were run between maps of gray matter volume, white matter integrity, and cerebral blood flow, and global/visceral obesity. Results: Negative associations were found in cognitively healthy individuals between obesity and white matter integrity and cerebral blood flow of temporo-parietal regions. In mild cognitive impairment, negative associations emerged in frontal, temporal, and brainstem regions. In mild dementia, a positive association was found between obesity and gray matter volume around the right temporoparietal junction. Conclusion: Obesity might contribute toward neural tissue vulnerability in cognitively healthy individuals and mild cognitive impairment, while a healthy weight in mild Alzheimer's disease dementia could help preserve brain structure in the presence of age and disease-related weight loss.

Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study / Dake, M. D.; De Marco, M.; Blackburn, D. J.; Wilkinson, I. D.; Remes, A.; Liu, Y.; Pikkarainen, M.; Hallikainen, M.; Soininen, H.; Venneri, A.. - In: JOURNAL OF ALZHEIMER'S DISEASE REPORTS. - ISSN 2542-4823. - 5:1(2021), pp. 65-77. [10.3233/ADR-200267]

Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study

De Marco M.;Venneri A.
2021-01-01

Abstract

Background: How the relationship between obesity and MRI-defined neural properties varies across distinct stages of cognitive impairment due to Alzheimer's disease is unclear. Objective: We used multimodal neuroimaging to clarify this relationship. Methods: Scans were acquired from 47 patients clinically diagnosed with mild Alzheimer's disease dementia, 68 patients with mild cognitive impairment, and 57 cognitively healthy individuals. Voxel-wise associations were run between maps of gray matter volume, white matter integrity, and cerebral blood flow, and global/visceral obesity. Results: Negative associations were found in cognitively healthy individuals between obesity and white matter integrity and cerebral blood flow of temporo-parietal regions. In mild cognitive impairment, negative associations emerged in frontal, temporal, and brainstem regions. In mild dementia, a positive association was found between obesity and gray matter volume around the right temporoparietal junction. Conclusion: Obesity might contribute toward neural tissue vulnerability in cognitively healthy individuals and mild cognitive impairment, while a healthy weight in mild Alzheimer's disease dementia could help preserve brain structure in the presence of age and disease-related weight loss.
2021
Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study / Dake, M. D.; De Marco, M.; Blackburn, D. J.; Wilkinson, I. D.; Remes, A.; Liu, Y.; Pikkarainen, M.; Hallikainen, M.; Soininen, H.; Venneri, A.. - In: JOURNAL OF ALZHEIMER'S DISEASE REPORTS. - ISSN 2542-4823. - 5:1(2021), pp. 65-77. [10.3233/ADR-200267]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2933255
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