We retrospectively investigated mother-to-infant transmission of group B Streptococcus (GBS) in 98 cases of lateonset disease reported during 2007–2018 by a network in Italy. Mothers with full assessment of vaginal/rectal carriage tested at prenatal screening (APS) and at time of late onset (ATLO) were included. Thirty-three mothers (33.7%) were never GBS colonized; 65 (66.3%) were vaginal/rectal colonized, of which 36 (36.7%) were persistently colonized. Mothers with vaginal/rectal colonization ATLO had high rates of GBS bacteriuria (33.9%) and positive breast milk culture (27.5%). GBS strains from mother– infant pairs were serotype III and possessed the surface protein antigen Rib. All but 1 strain belonged to clonal complex 17. GBS strains from 4 mother–infant pairs were indistinguishable through pulsed-fi eld gel electrophoresis. At least two thirds of late-onset cases are transmitted from mothers, who often have vaginal/rectal carriage, positive breast milk culture, or GBS bacteriuria, which suggests heavy maternal colonization.
Maternal Carriage in Late-Onset Group B Streptococcus Disease, Italy / Alberto, Berardi; Caterina, Spada; Roberta, Creti; Cinzia, Auriti; Lucia, Gambini; Vittoria, Rizzo; Mariagrazia, Capretti; Nicola, Laforgia; Irene, Papa; Anna, Tarocco; Angela, Lanzoni; Biasucci, G; Giancarlo, Piccinini; Giovanna, Nardella; Giuseppe, Latorre; Daniele, Merazzi; Laura, Travan; Maria Letizia Bacchi, Reggiani; Lorenza, Baroni; Matilde, Ciccia; Laura, Lucaccioni; Lorenzo, Iughetti; Licia, Lugli. - In: EMERGING INFECTIOUS DISEASES. - ISSN 1080-6059. - 27:(2021), pp. 2279-2287. [10.3201/eid2709.210049]
Maternal Carriage in Late-Onset Group B Streptococcus Disease, Italy
Biasucci G;
2021-01-01
Abstract
We retrospectively investigated mother-to-infant transmission of group B Streptococcus (GBS) in 98 cases of lateonset disease reported during 2007–2018 by a network in Italy. Mothers with full assessment of vaginal/rectal carriage tested at prenatal screening (APS) and at time of late onset (ATLO) were included. Thirty-three mothers (33.7%) were never GBS colonized; 65 (66.3%) were vaginal/rectal colonized, of which 36 (36.7%) were persistently colonized. Mothers with vaginal/rectal colonization ATLO had high rates of GBS bacteriuria (33.9%) and positive breast milk culture (27.5%). GBS strains from mother– infant pairs were serotype III and possessed the surface protein antigen Rib. All but 1 strain belonged to clonal complex 17. GBS strains from 4 mother–infant pairs were indistinguishable through pulsed-fi eld gel electrophoresis. At least two thirds of late-onset cases are transmitted from mothers, who often have vaginal/rectal carriage, positive breast milk culture, or GBS bacteriuria, which suggests heavy maternal colonization.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
