Screen-printed electrode modified with Co-NPs, as an electrochemical sensor for simultaneous determination of doxorubicin and dasatinib

The new metal complex of Co(II) (a1) and its nano-size, (a2), with NCS− and 5,5´-dimethyl-2,2´-bipyridine ligands have been synthesized. [Co(5,5´-dmbpy)3][Co(NCS)4] (a1) characterized through spectroscopic methods such as FTIR, UV–Vis, diffractometric analysis and elemental analysis. Nanoparticle (a2) has been identified with FTIR spectroscopy, also SEM, and XRD techniques. The size of the (a2) is about 86 nm. In this study, an electrochemical sensing platform for simultaneous detection of doxorubicin and dasatinib based on screen-printed electrode (SPE) modified with (a2) was prepared. The modified SPE, on the contrary to bare SPE, can considerably enhance activities of electrocatalytic towards oxidation of doxorubicin and dasatinib, followed by rising the anodic peak current. Peak currents obtained via differential pulse voltammetry (DPV) showed a linear enhancement as dasatinib concentration elevated and sensor detected in ranges more than that of the concentration limited area of 0.04–195.0 μM, detection limit equal to 12.0 nM (S/N = 3). DPV responses show that at the surface of modified SPE, obvious separation of the peak of doxorubicin and dasatinib oxidation has been reported from another with 400 mV potential difference between them. A lower limit of detection (LOD), higher sensitivity as well as stability resulted in an electrode that could be applied for analyzing different real compounds. Moreover, its functionality is favorable and desirable in analyzing biological fluids and drug compounds.