Aims: The primary aim of this study was to assess the reliability, intra- and inter-observer variation of the SPICE, Mucosal protrusion angle (MPA) and SHYUNG scores in differentiating a subepithelial mass (SEM) from a bulge. Methods: This retrospective multicentre study analysed the 3 scores, radiological studies, enteroscopy and/or surgical findings. Results: 100 patients with a potential SEM (mean age 57.6years) were recruited with 75 patients having pathology. In patients with a SEM the mean SPICE score was 2.04 (95% CI 1.82–2.26) as compared to 1.16 (95% CI 0.81–1.51) without any pathology (AUC 0.74, p<0.001), with a fair intra-observer agreement (Kappa 0.3, p<0.001) and slight inter-observer agreement (Kappa 0.14, p<0.05). SPICE had a 37.3% sensitivity and 92.0% specificity in distinguishing between a SEM and bulge, whereas MPA<90˚ had 58.7% and 76.0% respectively, with poor intra-observer(p = 0.05) and interobserver agreement (p = 0.64). The SHYUNG demonstrated a moderate intra-observer (Kappa 0.44, p<0.001) and slight inter-observer reliability (Kappa 0.18, p<0.001). The sensitivity of an elevated SHYUNG score (≥4) in identifying a SEM was 18.7% with a specificity of 92.0% (AUC 0.71, p = 0.002). Conclusions: Though these scores are easy to use, they have, at best, slight to moderate intra and inter-observer agreement. Their overall diagnostic performances are limited.

Score reproducibility and reliability in differentiating small bowel subepithelial masses from innocent bulges / Sciberras, M.; Conti, K.; Elli, L.; Scaramella, L.; Riccioni, M. E.; Marmo, C.; Cadoni, S.; Mcalindon, M.; Sidhu, R.; O'Hara, F.; Mcnamara, D.; Rondonotti, E.; Piccirelli, S.; Spada, C.; Bruno, M.; Keuchel, M.; Baltes, P.; Calleja, N.; Valdivia, P. C.; De'Angelis, G. L.; Margalit-Yehuda, R.; Koulaouzidis, A.; Dray, X.; Ellul, P.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - (2022). [10.1016/j.dld.2022.06.027]

Score reproducibility and reliability in differentiating small bowel subepithelial masses from innocent bulges

de'Angelis G. L.;
2022

Abstract

Aims: The primary aim of this study was to assess the reliability, intra- and inter-observer variation of the SPICE, Mucosal protrusion angle (MPA) and SHYUNG scores in differentiating a subepithelial mass (SEM) from a bulge. Methods: This retrospective multicentre study analysed the 3 scores, radiological studies, enteroscopy and/or surgical findings. Results: 100 patients with a potential SEM (mean age 57.6years) were recruited with 75 patients having pathology. In patients with a SEM the mean SPICE score was 2.04 (95% CI 1.82–2.26) as compared to 1.16 (95% CI 0.81–1.51) without any pathology (AUC 0.74, p<0.001), with a fair intra-observer agreement (Kappa 0.3, p<0.001) and slight inter-observer agreement (Kappa 0.14, p<0.05). SPICE had a 37.3% sensitivity and 92.0% specificity in distinguishing between a SEM and bulge, whereas MPA<90˚ had 58.7% and 76.0% respectively, with poor intra-observer(p = 0.05) and interobserver agreement (p = 0.64). The SHYUNG demonstrated a moderate intra-observer (Kappa 0.44, p<0.001) and slight inter-observer reliability (Kappa 0.18, p<0.001). The sensitivity of an elevated SHYUNG score (≥4) in identifying a SEM was 18.7% with a specificity of 92.0% (AUC 0.71, p = 0.002). Conclusions: Though these scores are easy to use, they have, at best, slight to moderate intra and inter-observer agreement. Their overall diagnostic performances are limited.
Score reproducibility and reliability in differentiating small bowel subepithelial masses from innocent bulges / Sciberras, M.; Conti, K.; Elli, L.; Scaramella, L.; Riccioni, M. E.; Marmo, C.; Cadoni, S.; Mcalindon, M.; Sidhu, R.; O'Hara, F.; Mcnamara, D.; Rondonotti, E.; Piccirelli, S.; Spada, C.; Bruno, M.; Keuchel, M.; Baltes, P.; Calleja, N.; Valdivia, P. C.; De'Angelis, G. L.; Margalit-Yehuda, R.; Koulaouzidis, A.; Dray, X.; Ellul, P.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - (2022). [10.1016/j.dld.2022.06.027]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2929551
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