We report a strategy for the realization of NMR chemosensors based on the spontaneous self-assembly of lower rim pyridiniumfunctionalized tetraphopshonate cavitands on commercial silica nanoparticles. These nanohybrids enable the selective detection of physiologically relevant N-methylated amines, with a limit of detection of 31 mM, via STD-based NMR experiments, achieving for the first time fine structural selectivity in nanoparticle-assisted NMR chemosensing.
Selective NMR detection of N-methylated amines using cavitand-decorated silica nanoparticles as receptors / Cesari, Andrea; Rosa-Gastaldo, Daniele; Pedrini, Alessandro; Rastrelli, Federico; Dalcanale, Enrico; Pinalli, Roberta; Mancin, Fabrizio. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 58:(2022), pp. 10861-10864. [10.1039/D2CC04199E]