Biologics are currently one of the main treatment options for a number of diseases. The IgG4 monoclonal antibody dupilumab targets the Interleukin-4 receptor alpha chain, thus preventing the biological effects of the cytokines IL-4 and IL-13, that are essential for the Th2 response. Several controlled trials showed that dupilumab is effective and safe in patients with atopic dermatitis (AD), severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), thus resulting in approval by regulatory agencies. Aim of the study was to evaluate the efficacy and safety of dupilumab in adult patients with CRSwNP stratified by common overlapping comorbid conditions.

Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life / Nettis, Eustachio; Brussino, Luisa; Patella, Vincenzo; Bonzano, Laura; Detoraki, Aikaterini; Di Leo, Elisabetta; Sirufo, Maria Maddalena; Caruso, Cristiano; Lodi Rizzini, Fabio; Conte, Mariaelisabetta; Yacoub, Mona-Rita; Triggiani, Massimo; Ridolo, Erminia; Macchia, Luigi; Rolla, Giovanni; Brancaccio, Raffaele; De Paulis, Amato; Spadaro, Giuseppe; Di Bona, Danilo; D'Uggento, Angela Maria; Ginaldi, Lia; Gaeta, Francesco; Nucera, Eleonora; Jaubashi, Kliljeda; Villalta, Danilo; Dagna, Lorenzo; Ciotta, Domenico; Pucciarini, Francesco; Bagnasco, Diego; Celi, Giorgio; Chieco Bianchi, Fulvia; Cosmi, Lorenzo; Costantino, Maria Teresa; Crivellaro, Maria Angiola; D'Alò, Simona; Del Biondo, Pietro; Del Giacco, Stefano; Di Gioacchino, Mario; Di Pietro, Linda; Favero, Elisabetta; Gangemi, Sebastiano; Guarnieri, Gabriella; Heffler, Enrico; Leto Barone, Maria Stefania; Lombardo, Carla; Losa, Francesca; Matucci, Andrea; Minciullo, Paola Lucia; Parronchi, Paola; Passalacqua, Giovanni; Pucci, Stefano; Rossi, Oliviero; Salvati, Lorenzo; Schiappoli, Michele; Senna, Gianenrico; Vianello, Andrea; Vultaggio, Alessandra; Baoran, Yang; Incorvaia, Cristoforo; Canonica, Giorgio Walter. - In: CLINICAL AND MOLECULAR ALLERGY. - ISSN 1476-7961. - 20:1(2022), p. 6. [10.1186/s12948-022-00171-2]

Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life

Ridolo, Erminia;
2022

Abstract

Biologics are currently one of the main treatment options for a number of diseases. The IgG4 monoclonal antibody dupilumab targets the Interleukin-4 receptor alpha chain, thus preventing the biological effects of the cytokines IL-4 and IL-13, that are essential for the Th2 response. Several controlled trials showed that dupilumab is effective and safe in patients with atopic dermatitis (AD), severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), thus resulting in approval by regulatory agencies. Aim of the study was to evaluate the efficacy and safety of dupilumab in adult patients with CRSwNP stratified by common overlapping comorbid conditions.
Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life / Nettis, Eustachio; Brussino, Luisa; Patella, Vincenzo; Bonzano, Laura; Detoraki, Aikaterini; Di Leo, Elisabetta; Sirufo, Maria Maddalena; Caruso, Cristiano; Lodi Rizzini, Fabio; Conte, Mariaelisabetta; Yacoub, Mona-Rita; Triggiani, Massimo; Ridolo, Erminia; Macchia, Luigi; Rolla, Giovanni; Brancaccio, Raffaele; De Paulis, Amato; Spadaro, Giuseppe; Di Bona, Danilo; D'Uggento, Angela Maria; Ginaldi, Lia; Gaeta, Francesco; Nucera, Eleonora; Jaubashi, Kliljeda; Villalta, Danilo; Dagna, Lorenzo; Ciotta, Domenico; Pucciarini, Francesco; Bagnasco, Diego; Celi, Giorgio; Chieco Bianchi, Fulvia; Cosmi, Lorenzo; Costantino, Maria Teresa; Crivellaro, Maria Angiola; D'Alò, Simona; Del Biondo, Pietro; Del Giacco, Stefano; Di Gioacchino, Mario; Di Pietro, Linda; Favero, Elisabetta; Gangemi, Sebastiano; Guarnieri, Gabriella; Heffler, Enrico; Leto Barone, Maria Stefania; Lombardo, Carla; Losa, Francesca; Matucci, Andrea; Minciullo, Paola Lucia; Parronchi, Paola; Passalacqua, Giovanni; Pucci, Stefano; Rossi, Oliviero; Salvati, Lorenzo; Schiappoli, Michele; Senna, Gianenrico; Vianello, Andrea; Vultaggio, Alessandra; Baoran, Yang; Incorvaia, Cristoforo; Canonica, Giorgio Walter. - In: CLINICAL AND MOLECULAR ALLERGY. - ISSN 1476-7961. - 20:1(2022), p. 6. [10.1186/s12948-022-00171-2]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2926453
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