Abstract: T cell-mediated adaptive immunity is designed to respond to non-self antigens and pathogens through the activation and proliferation of various T cell populations. T helper 1 (Th1), Th2, Th17 and Treg cells finely orchestrate cellular responses through a plethora of paracrine and autocrine stimuli that include cytokines, autacoids, and hormones. Hydrogen sulfide (H2S) is one of these mediators able to induce/inhibit immunological responses, playing a role in inflammatory and autoimmune diseases, neurological disorders, asthma, acute pancreatitis, and sepsis. Both endogenous and exogenous H2S modulate numerous important cell signaling pathways. In monocytes, polymorphonuclear, and T cells H2S impacts on activation, survival, proliferation, polarization, adhesion pathways, and modulates cytokine production and sensitivity to chemokines. Here, we offer a comprehensive review on the role of H2S as a natural buffer able to maintain over time a functional balance between Th1, Th2, Th17 and Treg immunological responses.

Buffering Adaptive Immunity by Hydrogen Sulfide / Pozzi, G; Gobbi, G; Masselli, E; Carubbi, C; Presta, V; Ambrosini, L; Vitale, M; Mirandola, P.. - In: CELLS. - ISSN 2073-4409. - 11(2022). [10.3390/cells11030325]

Buffering Adaptive Immunity by Hydrogen Sulfide

Pozzi G;Gobbi G;Masselli E
;
Carubbi C;Presta V;Ambrosini L;Vitale M;Mirandola P.
2022

Abstract

Abstract: T cell-mediated adaptive immunity is designed to respond to non-self antigens and pathogens through the activation and proliferation of various T cell populations. T helper 1 (Th1), Th2, Th17 and Treg cells finely orchestrate cellular responses through a plethora of paracrine and autocrine stimuli that include cytokines, autacoids, and hormones. Hydrogen sulfide (H2S) is one of these mediators able to induce/inhibit immunological responses, playing a role in inflammatory and autoimmune diseases, neurological disorders, asthma, acute pancreatitis, and sepsis. Both endogenous and exogenous H2S modulate numerous important cell signaling pathways. In monocytes, polymorphonuclear, and T cells H2S impacts on activation, survival, proliferation, polarization, adhesion pathways, and modulates cytokine production and sensitivity to chemokines. Here, we offer a comprehensive review on the role of H2S as a natural buffer able to maintain over time a functional balance between Th1, Th2, Th17 and Treg immunological responses.
Buffering Adaptive Immunity by Hydrogen Sulfide / Pozzi, G; Gobbi, G; Masselli, E; Carubbi, C; Presta, V; Ambrosini, L; Vitale, M; Mirandola, P.. - In: CELLS. - ISSN 2073-4409. - 11(2022). [10.3390/cells11030325]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2917999
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