Several thiazolyl/benzothiazolyl/benzo[d] isothiazolyl Schiff bases and hydrazones have been tested as anti-inflammatory agents and five new compounds have been synthesized. The anti-inflammatory activity was examined in vivo using the carrageenin induced mice paw edema test (inhibition 16.3-64 %). The compounds were tested for antioxidant activity as hydroxyl scavengers and for their ability to interact with the stable free radical 1,1-diphenyl-2-picryl- hydrazyl (DPPH). Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.
Thiazolyl and isothiazolyl azomethine derivatives with anti-inflammatory and antioxidant activities / Geronikaki, A.; Vicini, P.; Incerti, M.; Hadjipavlou-Litina, D.. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - 54:9(2004), pp. 530-537. [10.1055/s-0031-1297008]
Thiazolyl and isothiazolyl azomethine derivatives with anti-inflammatory and antioxidant activities
Vicini P.Membro del Collaboration Group
;Incerti M.Membro del Collaboration Group
;
2004-01-01
Abstract
Several thiazolyl/benzothiazolyl/benzo[d] isothiazolyl Schiff bases and hydrazones have been tested as anti-inflammatory agents and five new compounds have been synthesized. The anti-inflammatory activity was examined in vivo using the carrageenin induced mice paw edema test (inhibition 16.3-64 %). The compounds were tested for antioxidant activity as hydroxyl scavengers and for their ability to interact with the stable free radical 1,1-diphenyl-2-picryl- hydrazyl (DPPH). Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
