Several thiazolyl/benzothiazolyl/benzo[d] isothiazolyl Schiff bases and hydrazones have been tested as anti-inflammatory agents and five new compounds have been synthesized. The anti-inflammatory activity was examined in vivo using the carrageenin induced mice paw edema test (inhibition 16.3-64 %). The compounds were tested for antioxidant activity as hydroxyl scavengers and for their ability to interact with the stable free radical 1,1-diphenyl-2-picryl- hydrazyl (DPPH). Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.

Thiazolyl and isothiazolyl azomethine derivatives with anti-inflammatory and antioxidant activities / Geronikaki, A.; Vicini, P.; Incerti, M.; Hadjipavlou-Litina, D.. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - 54:9(2004), pp. 530-537. [10.1055/s-0031-1297008]

Thiazolyl and isothiazolyl azomethine derivatives with anti-inflammatory and antioxidant activities

Vicini P.
Membro del Collaboration Group
;
Incerti M.
Membro del Collaboration Group
;
2004-01-01

Abstract

Several thiazolyl/benzothiazolyl/benzo[d] isothiazolyl Schiff bases and hydrazones have been tested as anti-inflammatory agents and five new compounds have been synthesized. The anti-inflammatory activity was examined in vivo using the carrageenin induced mice paw edema test (inhibition 16.3-64 %). The compounds were tested for antioxidant activity as hydroxyl scavengers and for their ability to interact with the stable free radical 1,1-diphenyl-2-picryl- hydrazyl (DPPH). Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.
2004
Thiazolyl and isothiazolyl azomethine derivatives with anti-inflammatory and antioxidant activities / Geronikaki, A.; Vicini, P.; Incerti, M.; Hadjipavlou-Litina, D.. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - 54:9(2004), pp. 530-537. [10.1055/s-0031-1297008]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2914248
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