Objectives: stereotactic body radiation therapy (SBRT) use has increased overtime for the management of metastatic renal cell carcinoma (mRCC) patients, with a likely good control of irradiated lesions. We planned a retrospective multicenter Italian study, with the aim of investigating the outcome of treatment with SBRT for non-brain secondary lesions in mRCC patients. Methods: all consecutive metastatic non-brain lesions from mRCC that underwent SBRT at nine Italian institutions from January 2015 to June 2017 were considered. The primary endpoint of the study was the lesion-PFS, calculated from SBRT initiation to the local progression of the irradiated lesion. Results: 57 extracranial metastatic lesions from 48 patients with primary mRCC were treated with SBRT. At the median follow-up of 26.4 months, the median lesion-PFS was not reached (43 censored); 72.4% of lesions were progression-free at 40 months, with significantly better lesion-PFS for small metastatic lesions (<14 mm). SBRT was safe and the 1-year local disease control was 87.7%. After SBRT, 18 patients (37.5%) permanently interrupted systemic therapy. Conclusions: consistently with the previous literature, our findings support the use of SBRT in selected mRCC patients.

Treatment Outcome of metastatic lesions from renal cell carcinoma underGoing Extra-cranial stereotactic body radioTHERapy: The together retrospective study / Buti, S.; Bersanelli, M.; Viansone, A.; Leonetti, A.; Masini, C.; Ratta, R.; Procopio, G.; Maines, F.; Iacovelli, R.; Ciccarese, C.; Vitale, M. G.; De Giorgi, U.; Mucciarini, C.; Maruzzo, M.; Prati, G.; Lattanzi, E.; Ciammella, P.; Bruni, A.; Andreani, S.; D'Abbiero, N.. - In: CANCER TREATMENT AND RESEARCH COMMUNICATIONS. - ISSN 2468-2942. - 22:(2020), p. 100161.100161. [10.1016/j.ctarc.2019.100161]

Treatment Outcome of metastatic lesions from renal cell carcinoma underGoing Extra-cranial stereotactic body radioTHERapy: The together retrospective study

Buti S.;Bersanelli M.;Leonetti A.;Lattanzi E.;Andreani S.;D'Abbiero N.
2020

Abstract

Objectives: stereotactic body radiation therapy (SBRT) use has increased overtime for the management of metastatic renal cell carcinoma (mRCC) patients, with a likely good control of irradiated lesions. We planned a retrospective multicenter Italian study, with the aim of investigating the outcome of treatment with SBRT for non-brain secondary lesions in mRCC patients. Methods: all consecutive metastatic non-brain lesions from mRCC that underwent SBRT at nine Italian institutions from January 2015 to June 2017 were considered. The primary endpoint of the study was the lesion-PFS, calculated from SBRT initiation to the local progression of the irradiated lesion. Results: 57 extracranial metastatic lesions from 48 patients with primary mRCC were treated with SBRT. At the median follow-up of 26.4 months, the median lesion-PFS was not reached (43 censored); 72.4% of lesions were progression-free at 40 months, with significantly better lesion-PFS for small metastatic lesions (<14 mm). SBRT was safe and the 1-year local disease control was 87.7%. After SBRT, 18 patients (37.5%) permanently interrupted systemic therapy. Conclusions: consistently with the previous literature, our findings support the use of SBRT in selected mRCC patients.
Treatment Outcome of metastatic lesions from renal cell carcinoma underGoing Extra-cranial stereotactic body radioTHERapy: The together retrospective study / Buti, S.; Bersanelli, M.; Viansone, A.; Leonetti, A.; Masini, C.; Ratta, R.; Procopio, G.; Maines, F.; Iacovelli, R.; Ciccarese, C.; Vitale, M. G.; De Giorgi, U.; Mucciarini, C.; Maruzzo, M.; Prati, G.; Lattanzi, E.; Ciammella, P.; Bruni, A.; Andreani, S.; D'Abbiero, N.. - In: CANCER TREATMENT AND RESEARCH COMMUNICATIONS. - ISSN 2468-2942. - 22:(2020), p. 100161.100161. [10.1016/j.ctarc.2019.100161]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2913526
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