The first example of palladium-catalysed oxidative carbonylation of unprotected α-amino amides to hydantoins is described here. The selective synthesis of the target compounds was achieved under mild conditions (1 atm of CO), without ligands and bases. The catalytic system overrode the common reaction pathway that usually leads instead to the formation of symmetrical ureas.
Pd-Catalysed oxidative carbonylation of α-amino amides to hydantoins under mild conditions / Voronov, A.; Botla, V.; Montanari, L.; Carfagna, C.; Mancuso, R.; Gabriele, B.; Maestri, G.; Motti, E.; Della Ca', N.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 58:2(2022), pp. 294-297. [10.1039/d1cc04154a]
Pd-Catalysed oxidative carbonylation of α-amino amides to hydantoins under mild conditions
Voronov A.;Botla V.;Montanari L.;Maestri G.;Motti E.;Della Ca' N.
2022-01-01
Abstract
The first example of palladium-catalysed oxidative carbonylation of unprotected α-amino amides to hydantoins is described here. The selective synthesis of the target compounds was achieved under mild conditions (1 atm of CO), without ligands and bases. The catalytic system overrode the common reaction pathway that usually leads instead to the formation of symmetrical ureas.| File | Dimensione | Formato | |
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