One of the emerging global health threats is the drug-resistant microbial diseases that could cause millions of deaths each year by 2050. A very promising tool to tackle antimicrobial resistance is photodynamic therapy that exploits the ability of a photosensitizer to generate oxidizing species upon illumination to kill bacteria. The research activity in this field is very active and, following this approach, we aim to develop a targeted theranostic agent where a protein is used as a “modular” carrier, transporting a fluorescent photosensitizer, and an antibody to confer selectivity to the photodynamic effect.
Photosensitizing proteins for a targeted antibacterial photodynamic inactivation / Mussini, A.; Hally, C.; Viappiani, C.; Nonell, S.; Bonsfills, M. A.; Abbruzzetti, S.. - In: IL NUOVO CIMENTO C. - ISSN 2037-4909. - 44:4-5(2021). [10.1393/ncc/i2021-21122-6]
Photosensitizing proteins for a targeted antibacterial photodynamic inactivation
Mussini A.;Viappiani C.;Abbruzzetti S.
2021-01-01
Abstract
One of the emerging global health threats is the drug-resistant microbial diseases that could cause millions of deaths each year by 2050. A very promising tool to tackle antimicrobial resistance is photodynamic therapy that exploits the ability of a photosensitizer to generate oxidizing species upon illumination to kill bacteria. The research activity in this field is very active and, following this approach, we aim to develop a targeted theranostic agent where a protein is used as a “modular” carrier, transporting a fluorescent photosensitizer, and an antibody to confer selectivity to the photodynamic effect.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
