Background: Few data are available regarding the effectiveness of immune checkpoint inhibitors in advanced upper tract urothelial carcinoma (UTUC) patients. Methods: To provide a real-world experience with anti-PD-1/PD-L1-based therapy in UTUC patients, we involved an Italian network in a multicenter retrospective analysis. Results: A total of 78 UTUC patients were enrolled. The median follow-up was 25.1 months. The median progression-free survival (mPFS) was 2.2 months (95% CI 1.8-2.6), and the median OS (mOS) was 6.0 months (95% CI 3.6-8.4). The Sonpavde score (including performance status > 0, hemoglobin < 10 g/dl, liver metastases, time from prior chemotherapy >= 3 months) split the patients into three groups (0 vs 1 vs 2-4 factors), efficiently predicting the OS and PFS outcome at the multivariate analyses (p < 0.0001). Conclusion: The prognosis of unselected UTUC patients is still unsatisfactory. The Sonpavde score was validated for the first time in an UTUC population, as a useful tool for the treatment decision-making process.
Immunotherapy and Sonpavde score validation in advanced upper tract urothelial carcinoma: a retrospective study by the Italian Network for Research in Urologic-Oncology / Bersanelli, Melissa; Mazzaschi, Giulia; Giannatempo, Patrizia; Raggi, Daniele; Farè, Elena; Maruzzo, Marco; Basso, Umberto; De Giorgi, Ugo; Vignani, Francesca; Banna, Giuseppe Luigi; Stellato, Marco; Tambaro, Rosa; Naglieri, Emanuele; Losanno, Tania; Procopio, Giuseppe; Pignata, Sandro; Necchi, Andrea; Buti, Sebastiano. - In: IMMUNOTHERAPY. - ISSN 1750-743X. - (2021). [10.2217/imt-2021-0109]
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