BACKGROUNDNon-clear cell (ncc) metastatic renal-cell carcinoma (RCC) has dismal results with standard systemic therapies and a generally worse prognosis when compared to its clear-cell counterpart. New systemic combination therapies have emerged for metastatic RCC (mRCC), but the pivotal phase III trials excluded patients with nccRCC, which constitute about 30% of metastatic RCC cases.AIMTo provide a piece of real-life evidence on the use of pazopanib in this patient subgroup.METHODSThe present study is a multicenter retrospective observational analysis aiming to assess the activity, efficacy, and safety of pazopanib as first-line therapy for advanced nccRCC patients treated in a real-life setting.RESULTSOverall, 48 patients were included. At the median follow-up of 40.6 mo, the objective response rate was 27.1%, the disease control rate was 83.3%, and the median progression-free survival and overall survival were 12.3 (95% confidence interval [CI]: 3.6-20.9) and 27.7 (95%CI: 18.2-37.1) mo, respectively. Grade 3 adverse events occurred in 20% of patients, and no grade 4 or 5 toxicities were found.CONCLUSIONPazopanib should be considered as a good first-line option for metastatic RCC with variant histology.

First-line pazopanib in patients with advanced non-clear cell renal carcinoma: An Italian case series / Buti, Sebastiano; Bersanelli, Melissa; Massari, Francesco; De Giorgi, Ugo; Caffo, Orazio; Aurilio, Gaetano; Basso, Umberto; Carteni, Giacomo; Caserta, Claudia; Galli, Luca; Boccardo, Francesco; Procopio, Giuseppe; Facchini, Gaetano; Fornarini, Giuseppe; Berruti, Alfredo; Fea, Elena; Naglieri, Emanuele; Petrelli, Fausto; Iacovelli, Roberto; Porta, Camillo; Mosca, Alessandra. - In: WORLD JOURNAL OF CLINICAL ONCOLOGY. - ISSN 2218-4333. - 12:11(2021), pp. 1037-1046-1046. [10.5306/wjco.v12.i11.1037]

First-line pazopanib in patients with advanced non-clear cell renal carcinoma: An Italian case series

Buti, Sebastiano;Bersanelli, Melissa
;
2021

Abstract

BACKGROUNDNon-clear cell (ncc) metastatic renal-cell carcinoma (RCC) has dismal results with standard systemic therapies and a generally worse prognosis when compared to its clear-cell counterpart. New systemic combination therapies have emerged for metastatic RCC (mRCC), but the pivotal phase III trials excluded patients with nccRCC, which constitute about 30% of metastatic RCC cases.AIMTo provide a piece of real-life evidence on the use of pazopanib in this patient subgroup.METHODSThe present study is a multicenter retrospective observational analysis aiming to assess the activity, efficacy, and safety of pazopanib as first-line therapy for advanced nccRCC patients treated in a real-life setting.RESULTSOverall, 48 patients were included. At the median follow-up of 40.6 mo, the objective response rate was 27.1%, the disease control rate was 83.3%, and the median progression-free survival and overall survival were 12.3 (95% confidence interval [CI]: 3.6-20.9) and 27.7 (95%CI: 18.2-37.1) mo, respectively. Grade 3 adverse events occurred in 20% of patients, and no grade 4 or 5 toxicities were found.CONCLUSIONPazopanib should be considered as a good first-line option for metastatic RCC with variant histology.
First-line pazopanib in patients with advanced non-clear cell renal carcinoma: An Italian case series / Buti, Sebastiano; Bersanelli, Melissa; Massari, Francesco; De Giorgi, Ugo; Caffo, Orazio; Aurilio, Gaetano; Basso, Umberto; Carteni, Giacomo; Caserta, Claudia; Galli, Luca; Boccardo, Francesco; Procopio, Giuseppe; Facchini, Gaetano; Fornarini, Giuseppe; Berruti, Alfredo; Fea, Elena; Naglieri, Emanuele; Petrelli, Fausto; Iacovelli, Roberto; Porta, Camillo; Mosca, Alessandra. - In: WORLD JOURNAL OF CLINICAL ONCOLOGY. - ISSN 2218-4333. - 12:11(2021), pp. 1037-1046-1046. [10.5306/wjco.v12.i11.1037]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2908348
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