In children with cancer, chemotherapy can produce cytotoxic effects, resulting in immuno-suppression and an augmented risk of febrile neutropenia and bloodstream infections. This has led to widespread use of antibiotic prophylaxis which, combined with intensive chemotherapy treatment, could have a long-term effect on the gastrointestinal microbiome. In this review, we aimed to analyze the current literature about the widespread use of antibiotic prophylaxis in children experiencing infectious complications induced by chemotherapy and its effects on the gut microbiome. Our review of the literature shows that antimicrobial prophylaxis in children with cancer is still a trending topic and, at the moment, there are not enough data to define universal guidelines. Children with cancer experience long and painful medical treatments and side effects, which are associated with great economic and social burdens, important psychological consequences, and dysbiosis induced by antibiotics and also by chemotherapy. Considering the importance of a healthy gut microbiota, studies are needed to understand the impact of dysbiosis in response to therapy in these children and to define how to modulate the microbiome to favor a positive therapeutic outcome.

Antimicrobial prophylaxis and modifications of the gut microbiota in children with cancer / Bossu, G.; Di Sario, R.; Argentiero, A.; Esposito, S.. - In: ANTIBIOTICS. - ISSN 2079-6382. - 10:2(2021), pp. 152.1-152.15. [10.3390/antibiotics10020152]

Antimicrobial prophylaxis and modifications of the gut microbiota in children with cancer

Di Sario R.;Argentiero A.;Esposito S.
2021

Abstract

In children with cancer, chemotherapy can produce cytotoxic effects, resulting in immuno-suppression and an augmented risk of febrile neutropenia and bloodstream infections. This has led to widespread use of antibiotic prophylaxis which, combined with intensive chemotherapy treatment, could have a long-term effect on the gastrointestinal microbiome. In this review, we aimed to analyze the current literature about the widespread use of antibiotic prophylaxis in children experiencing infectious complications induced by chemotherapy and its effects on the gut microbiome. Our review of the literature shows that antimicrobial prophylaxis in children with cancer is still a trending topic and, at the moment, there are not enough data to define universal guidelines. Children with cancer experience long and painful medical treatments and side effects, which are associated with great economic and social burdens, important psychological consequences, and dysbiosis induced by antibiotics and also by chemotherapy. Considering the importance of a healthy gut microbiota, studies are needed to understand the impact of dysbiosis in response to therapy in these children and to define how to modulate the microbiome to favor a positive therapeutic outcome.
Antimicrobial prophylaxis and modifications of the gut microbiota in children with cancer / Bossu, G.; Di Sario, R.; Argentiero, A.; Esposito, S.. - In: ANTIBIOTICS. - ISSN 2079-6382. - 10:2(2021), pp. 152.1-152.15. [10.3390/antibiotics10020152]
File in questo prodotto:
File Dimensione Formato  
31. Antimicrobial Prophylaxis and Modifications of the Gut Microbiota in Children with Cancer_Microorganisms.pdf

accesso aperto

Tipologia: Versione (PDF) editoriale
Licenza: Creative commons
Dimensione 334.53 kB
Formato Adobe PDF
334.53 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2907162
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact